Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
IRAK3 and HOXB7
Data Source:
BioGRID
(two hybrid)
IRAK3
HOXB7
Description
interleukin 1 receptor associated kinase 3
homeobox B7
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Chromatin
Nucleus
Nucleoplasm
Cytosol
Nuclear Body
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Cytokine-mediated Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Response To Virus
Positive Regulation Of Macrophage Tolerance Induction
Negative Regulation Of Macrophage Cytokine Production
Cytokine-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Peptidoglycan
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Protein-containing Complex Disassembly
Response To Exogenous DsRNA
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Multicellular Organism Development
Anterior/posterior Pattern Specification
Myeloid Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Skeletal System Morphogenesis
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling
Drugs
Fostamatinib
Diseases
GWAS
Smooth-surface caries (
24556642
)
White blood cell count (basophil) (
29403010
)
Hypertension (
27618447
)
LDL cholesterol levels (
32203549
)
Mean arterial pressure (
30487518
)
Pulse pressure (
28135244
27618447
)
Systolic blood pressure (
27618447
30487518
)
Interacting Genes
17 interacting genes:
ADH1B
ATP6V0B
CD14
CDCA5
COPB1
ECM1
FOLR1
HOXB7
IRAK1
IRAK2
LDB1
MYD88
NONO
NSA2
NTRK3
TICAM2
TRAF6
13 interacting genes:
APP
CLK3
CREBBP
CSNK2A1
EP300
GMNN
HOXB6
IRAK3
NFKBIA
PARP1
PBX1
PKNOX1
XRCC6
Entrez ID
11213
3217
HPRD ID
05123
00850
Ensembl ID
ENSG00000090376
ENSG00000260027
Uniprot IDs
Q9Y616
P09629
PDB IDs
5UKE
6RUU
6ZIW
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?