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IRAK3
Description
interleukin 1 receptor associated kinase 3
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Negative Regulation Of Cytokine-mediated Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Response To Virus
Positive Regulation Of Macrophage Tolerance Induction
Negative Regulation Of Macrophage Cytokine Production
Cytokine-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Peptidoglycan
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Protein-containing Complex Disassembly
Response To Exogenous DsRNA
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling
Drugs
Fostamatinib
Diseases
GWAS
Smooth-surface caries (
24556642
)
White blood cell count (basophil) (
29403010
)
Interacting Genes
17 interacting genes:
ADH1B
ATP6V0B
CD14
CDCA5
COPB1
ECM1
FOLR1
HOXB7
IRAK1
IRAK2
LDB1
MYD88
NONO
NSA2
NTRK3
TICAM2
TRAF6
Entrez ID
11213
HPRD ID
05123
Ensembl ID
ENSG00000090376
Uniprot IDs
Q9Y616
PDB IDs
5UKE
6RUU
6ZIW
Enriched GO Terms of Interacting Partners
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