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IRAK3 and COPB1
Data Source:
BioGRID
(two hybrid)
IRAK3
COPB1
Description
interleukin 1 receptor associated kinase 3
COPI coat complex subunit beta 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Golgi Membrane
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Golgi Apparatus
Golgi-associated Vesicle
Cytosol
Plasma Membrane
Membrane
COPI Vesicle Coat
Transport Vesicle
Secretory Granule Membrane
Intracellular Membrane-bounded Organelle
Tertiary Granule Membrane
Ficolin-1-rich Granule Membrane
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Structural Molecule Activity
Protein Binding
Biological Process
Negative Regulation Of Cytokine-mediated Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Response To Virus
Positive Regulation Of Macrophage Tolerance Induction
Negative Regulation Of Macrophage Cytokine Production
Cytokine-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Peptidoglycan
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Protein-containing Complex Disassembly
Response To Exogenous DsRNA
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Intracellular Protein Transport
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Intra-Golgi Vesicle-mediated Transport
Viral Process
Neutrophil Degranulation
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling
Neutrophil degranulation
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Fostamatinib
Diseases
GWAS
Smooth-surface caries (
24556642
)
White blood cell count (basophil) (
29403010
)
HDL cholesterol (
26780889
)
HDL cholesterol levels (
32203549
28334899
)
Height (
31562340
)
High chromosomal aberration frequency (total) (
31586183
)
Vitamin D levels (
25208829
)
Interacting Genes
17 interacting genes:
ADH1B
ATP6V0B
CD14
CDCA5
COPB1
ECM1
FOLR1
HOXB7
IRAK1
IRAK2
LDB1
MYD88
NONO
NSA2
NTRK3
TICAM2
TRAF6
44 interacting genes:
ADAM19
APP
ARCN1
ARF1
BCAR1
COPE
COPG1
COPG2
ERBIN
FOXB1
GORAB
GRB2
GTPBP4
HLA-DPB1
HLA-G
ID1
IRAK3
KCNK3
KDELR1
KIAA1328
LINC00839
LZTS1
LZTS2
NUB1
PDGFRB
PRKCE
PTEN
RGS2
RGS4
RHOQ
SCYL1
SERTAD1
SNTA1
SPTBN1
TANK
TAPBP
TMED10
TRIM37
TTYH2
UBC
UBQLN4
VPS18
WBP2
XRCC6
Entrez ID
11213
1315
HPRD ID
05123
02981
Ensembl ID
ENSG00000090376
ENSG00000129083
Uniprot IDs
Q9Y616
P53618
PDB IDs
5UKE
6RUU
6ZIW
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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