IRAK3 and CDCA5

Data Source:
BioGRID (two hybrid)

		IRAK3	CDCA5
Description		interleukin 1 receptor associated kinase 3	cell division cycle associated 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Chromatin Binding Protein Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Mitotic Cell Cycle Double-strand Break Repair Mitotic Sister Chromatid Cohesion Mitotic Chromosome Condensation Mitotic Metaphase Plate Congression Positive Regulation Of Exit From Mitosis Cell Division Regulation Of Cohesin Loading
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Resolution of Sister Chromatid Cohesion
Drugs		Fostamatinib
Diseases
GWAS		Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	9 interacting genes: CDK1 IRAK3 KDM1A NAA10 NAA11 RPAIN SENP2 TTLL3 XRCC6
Entrez ID		11213	113130
HPRD ID		05123	13016
Ensembl ID		ENSG00000090376	ENSG00000146670
Uniprot IDs		Q9Y616	A0A024R5D6 Q96FF9
PDB IDs		5UKE 6RUU 6ZIW
Enriched GO Terms of Interacting Partners?
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