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IRAK3 and ECM1
Data Source:
BioGRID
(two hybrid)
IRAK3
ECM1
Description
interleukin 1 receptor associated kinase 3
extracellular matrix protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Extracellular Region
Extracellular Space
Extracellular Matrix
Platelet Dense Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protease Binding
Interleukin-2 Receptor Binding
Extracellular Matrix Structural Constituent
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Laminin Binding
Biological Process
Negative Regulation Of Cytokine-mediated Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Response To Virus
Positive Regulation Of Macrophage Tolerance Induction
Negative Regulation Of Macrophage Cytokine Production
Cytokine-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Peptidoglycan
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Protein-containing Complex Disassembly
Response To Exogenous DsRNA
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Ossification
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cytokine-mediated Signaling Pathway
Chondrocyte Development
Platelet Degranulation
Regulation Of Type 2 Immune Response
Endochondral Bone Growth
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Signal Transduction
Negative Regulation Of Peptidase Activity
Regulation Of Bone Mineralization
Negative Regulation Of Bone Mineralization
Biomineral Tissue Development
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Angiogenesis
Regulation Of T Cell Migration
Pathways
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling
Platelet degranulation
Drugs
Fostamatinib
Diseases
Lipoid proteinosis; Urbach-Wiethe disease
GWAS
Smooth-surface caries (
24556642
)
White blood cell count (basophil) (
29403010
)
Blood protein levels (
28240269
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Migraine (
27322543
)
Refractive error (
32231278
)
Schizophrenia (
28991256
30285260
)
Spontaneous coronary artery dissection (
32887874
32374345
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
17 interacting genes:
ADH1B
ATP6V0B
CD14
CDCA5
COPB1
ECM1
FOLR1
HOXB7
IRAK1
IRAK2
LDB1
MYD88
NONO
NSA2
NTRK3
TICAM2
TRAF6
38 interacting genes:
A1CF
ACTN3
ATN1
BCAS2
BNIP3L
C1orf109
CPTP
CYSRT1
DDIAS
DTX2
ENKD1
FASLG
FBLN1
FKBP6
FRS3
GCM2
GNE
GPANK1
GRN
HOXC8
HSPG2
IRAK3
ITGB4
KLHL38
KRTAP5-3
KRTAP9-3
LCE2A
LIN7A
LMO4
MKRN3
PRKAR2B
RERE
SAMD11
SGTB
SNRPC
SRPK1
UBQLN1
UBQLN2
Entrez ID
11213
1893
HPRD ID
05123
03727
Ensembl ID
ENSG00000090376
ENSG00000143369
Uniprot IDs
Q9Y616
A0A140VJI7
Q16610
PDB IDs
5UKE
6RUU
6ZIW
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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