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TRIM14 and PLCG1
Data Source:
BioGRID
(two hybrid)
TRIM14
PLCG1
Description
tripartite motif containing 14
phospholipase C gamma 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Cytosol
Phagocytic Vesicle
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Lamellipodium
Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Molecular Function
Transcription Coactivator Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Glutamate Receptor Binding
Calcium-dependent Phospholipase C Activity
Biological Process
Protein Polyubiquitination
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Protein Ubiquitination
Regulation Of Protein Localization
Negative Regulation Of Viral Transcription
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
In Utero Embryonic Development
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Axon Guidance
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Phospholipase C Activity
Viral Process
Cell Migration
Calcium-mediated Signaling
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Inositol Phosphate Metabolic Process
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Interferon gamma signaling
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 point mutants in cancer
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS
Multiple sclerosis (
31604244
)
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Interacting Genes
84 interacting genes:
ABCF3
ADAMTS12
ALG13
AP3M1
ATP1B1
ATP1B3
ATP2A2
ATP5PB
ATP6V1H
BYSL
CARD9
CCDC125
CCDC57
CCDC6
CENPC
CIB3
CKS1B
CSPP1
EIF3G
ERCC3
ETFBKMT
EXOC8
FAM50B
FAT1
GOLGA2
GOLGA6L9
HERC3
HEXIM2
HNRNPF
IHO1
ITM2A
IVNS1ABP
KAT2B
KIF3A
KIFC3
LAMTOR1
LNX1
MAPRE3
MITD1
MNAT1
MRPL24
MYO15B
NCOR1
NDUFA9
NFAT5
NPC2
PCGF6
PDIA6
PHF11
PIM2
PLCG1
POLR1C
POLR2G
PPP2R3C
PRDM6
PRKAB2
PRPF31
PTPN21
RAB5A
RAB9A
RAD51D
RBM33
RLF
RNF125
RNF20
SLF2
SMARCB1
SMIM3
SPG21
STK38
TAX1BP1
TMEM167A
TRAF2
TSGA10
UBE2B
UBE2N
UNK
VIM
WDR35
WRNIP1
ZC4H2
ZFP36L2
ZGPAT
ZNF652
111 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
Entrez ID
9830
5335
HPRD ID
05948
01398
Ensembl ID
ENSG00000106785
ENSG00000124181
Uniprot IDs
A0A024R165
Q14142
P19174
Q4LE43
Q9UFY1
PDB IDs
6JBM
1HSQ
2HSP
4EY0
4FBN
Enriched GO Terms of Interacting Partners
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