TRIM14 and PDIA6

Data Source:
BioGRID (two hybrid)

		TRIM14	PDIA6
Description		tripartite motif containing 14	protein disulfide isomerase family A member 6
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Disulfide Isomerase Activity Protein Binding Peptide Disulfide Oxidoreductase Activity
	Biological Process	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Folding Protein Phosphopantetheinylation IRE1-mediated Unfolded Protein Response Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Interferon gamma signaling	XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		84 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	17 interacting genes: ATP13A2 CASP8 CLN8 CSNK2A1 GET3 LGALS9 LINC01554 MC4R MTNR1A MTNR1B SGTB SLC22A2 SLC2A4 SUMO4 TRIM14 UBE3A VKORC1
Entrez ID		9830	10130
HPRD ID		05948	07504
Ensembl ID		ENSG00000106785	ENSG00000143870
Uniprot IDs		A0A024R165 Q14142	A0A384NPU5 Q15084
PDB IDs		6JBM	1X5D 3VWW 3W8J 4EF0 4GWR
Enriched GO Terms of Interacting Partners?
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