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PLCG1 and NTRK1
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
PLCG1
NTRK1
Description
phospholipase C gamma 1
neurotrophic receptor tyrosine kinase 1
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Lamellipodium
Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Golgi Membrane
Early Endosome
Late Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Endosome Membrane
Axon
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Protein-containing Complex
Neuronal Cell Body
Receptor Complex
Recycling Endosome Membrane
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Glutamate Receptor Binding
Calcium-dependent Phospholipase C Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Neurotrophin Receptor Activity
Neurotrophin P75 Receptor Binding
Protein Binding
ATP Binding
Nerve Growth Factor Receptor Activity
Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Biological Process
In Utero Embryonic Development
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Axon Guidance
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Phospholipase C Activity
Viral Process
Cell Migration
Calcium-mediated Signaling
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Inositol Phosphate Metabolic Process
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Activation Of MAPKK Activity
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Aging
Learning Or Memory
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Response To Radiation
Programmed Cell Death Involved In Cell Development
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Olfactory Nerve Development
B Cell Differentiation
Response To Nutrient Levels
Positive Regulation Of Kinase Activity
Peptidyl-tyrosine Autophosphorylation
Nerve Growth Factor Signaling Pathway
Mechanoreceptor Differentiation
Response To Drug
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Sympathetic Nervous System Development
Response To Axon Injury
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To Hydrostatic Pressure
Response To Electrical Stimulus
Regulation Of Protein Kinase B Signaling
Positive Regulation Of Synapse Assembly
Positive Regulation Of Synaptic Transmission, Glutamatergic
Sertoli Cell Development
Axonogenesis Involved In Innervation
Behavioral Response To Formalin Induced Pain
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Nicotine
Cellular Response To Amyloid-beta
Cellular Response To Nerve Growth Factor Stimulus
Pathways
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 point mutants in cancer
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
PLC-gamma1 signalling
Signalling to RAS
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
NGF-independant TRKA activation
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
Drugs
Amitriptyline
Imatinib
Regorafenib
Entrectinib
Fostamatinib
Cenegermin
Larotrectinib
Pralsetinib
Diseases
Neuroblastoma
Thyroid cancer
GWAS
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Red cell distribution width (
32888494
)
Interacting Genes
111 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
40 interacting genes:
ABL1
ARHGAP32
CAV1
CRK
DNAJA3
DYNLL1
ERBB2
FRS2
FRS3
GIPC1
GRB2
IRS1
IRS2
KIDINS220
MAPK3
MATK
NEDD4L
NGF
NGFR
NTF3
PIK3R1
PLCG1
PTPN1
PTPN11
PTPRR
RAP1A
RASA1
RASGRF1
RUSC1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TPTE
TRAF4
TRAF6
UBB
Entrez ID
5335
4914
HPRD ID
01398
01869
Ensembl ID
ENSG00000124181
ENSG00000198400
Uniprot IDs
P19174
Q4LE43
Q9UFY1
P04629
X5DR71
PDB IDs
1HSQ
2HSP
4EY0
4FBN
1HE7
1SHC
1WWA
1WWW
2IFG
2N90
4AOJ
4CRP
4F0I
4GT5
4PMM
4PMP
4PMS
4PMT
4YNE
4YPS
5H3Q
5I8A
5JFS
5JFV
5JFW
5JFX
5KMI
5KMJ
5KMK
5KML
5KMM
5KMN
5KMO
5KVT
5WR7
6D1Y
6D1Z
6D20
6D22
6DKB
6DKG
6DKI
6DKW
6IQN
6J5L
6NPT
6NSP
6NSS
6PL1
6PL2
6PL3
6PL4
6PMA
6PMB
6PMC
6PME
Enriched GO Terms of Interacting Partners
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