TRIM14 and ALG13

Data Source:
BioGRID (two hybrid)

		TRIM14	ALG13
Description		tripartite motif containing 14	ALG13 UDP-N-acetylglucosaminyltransferase subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle	Endoplasmic Reticulum Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	RNA Binding N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity
	Biological Process	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Dolichol-linked Oligosaccharide Biosynthetic Process Proteolysis Protein Phosphopantetheinylation
Pathways		Interferon gamma signaling	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Rosacea symptom severity ( 29771307)
Interacting Genes		84 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	11 interacting genes: ATN1 ATXN1L BAG4 HOXA1 MAPKBP1 PITX1 RBFOX1 RERE RHOU ROR2 TRIM14
Entrez ID		9830	79868
HPRD ID		05948	06542
Ensembl ID		ENSG00000106785	ENSG00000101901
Uniprot IDs		A0A024R165 Q14142	A0A087WT15 A0A087WX43 Q9NP73
PDB IDs		6JBM
Enriched GO Terms of Interacting Partners?
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