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PLCG1 and NTRK2
Data Source:
HPRD
(in vitro, in vivo)
PLCG1
NTRK2
Description
phospholipase C gamma 1
neurotrophic receptor tyrosine kinase 2
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Lamellipodium
Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Golgi Membrane
Early Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Postsynaptic Density
Axon
Dendrite
Early Endosome Membrane
Terminal Bouton
Dendritic Spine
Receptor Complex
Axon Terminus
Perinuclear Region Of Cytoplasm
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Glutamate Receptor Binding
Calcium-dependent Phospholipase C Activity
Protease Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Neurotrophin Receptor Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Neurotrophin Binding
Brain-derived Neurotrophic Factor Binding
Brain-derived Neurotrophic Factor-activated Receptor Activity
Biological Process
In Utero Embryonic Development
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Axon Guidance
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Phospholipase C Activity
Viral Process
Cell Migration
Calcium-mediated Signaling
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Inositol Phosphate Metabolic Process
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Vasculogenesis
Neuron Migration
Positive Regulation Of Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Activation Of Phospholipase C Activity
Multicellular Organism Development
Learning
Circadian Rhythm
Feeding Behavior
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Glutamate Secretion
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Neuronal Action Potential Propagation
Central Nervous System Neuron Development
Cerebral Cortex Development
Myelination In Peripheral Nervous System
Neuron Differentiation
Brain-derived Neurotrophic Factor Receptor Signaling Pathway
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Kinase Activity
Mechanoreceptor Differentiation
Regulation Of GTPase Activity
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Retinal Rod Cell Development
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Oligodendrocyte Differentiation
Peripheral Nervous System Neuron Development
Positive Regulation Of Axonogenesis
Regulation Of Protein Kinase B Signaling
Positive Regulation Of Synapse Assembly
Long-term Synaptic Potentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Amino Acid Stimulus
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Trans-synaptic Signaling By Neuropeptide, Modulating Synaptic Transmission
Negative Regulation Of Amyloid-beta Formation
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Negative Regulation Of Anoikis
Pathways
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 point mutants in cancer
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
NGF-independant TRKA activation
BDNF activates NTRK2 (TRKB) signaling
NTF3 activates NTRK2 (TRKB) signaling
NTF4 activates NTRK2 (TRKB) signaling
Activated NTRK2 signals through RAS
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PI3K
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FYN
NTRK2 activates RAC1
NTRK2 activates RAC1
Activated NTRK2 signals through CDK5
Drugs
Amitriptyline
Esketamine
Entrectinib
Fostamatinib
Larotrectinib
Diseases
Neuroblastoma
GWAS
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Birth weight (
24950379
)
Body mass index (
28892062
25760438
)
Body size at age 10 (
32376654
)
Gout (normal type) (
32238385
)
Lifetime anxiety disorder (
31748690
)
Menarche (age at onset) (
25231870
)
Parkinson's disease progression (cognitive) (
33111402
)
Refractive error (
32231278
)
Serum metabolite concentrations in chronic kidney disease (
29545352
)
Type 2 diabetes (
31118516
)
Waist-to-hip circumference ratio (recreational physical activity interaction) (
23192594
)
Interacting Genes
111 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
34 interacting genes:
AP1B1
BDNF
DOK5
DYNLL1
EGFR
ERBB2
ERBB4
FRS2
FRS3
FYN
GIPC1
KIDINS220
NCK1
NCK2
NDFIP1
NGFR
NMNAT1
NTF3
NTF4
PIK3R1
PLCG1
POLR2G
PTPN1
PTPN11
RASGRF1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TRAF6
UBB
Entrez ID
5335
4915
HPRD ID
01398
02712
Ensembl ID
ENSG00000124181
ENSG00000148053
Uniprot IDs
P19174
Q4LE43
Q9UFY1
A0A024R230
Q16620
Q548C2
Q5VWE5
PDB IDs
1HSQ
2HSP
4EY0
4FBN
1HCF
1WWB
2MFQ
4ASZ
4AT3
4AT4
4AT5
5MO9
Enriched GO Terms of Interacting Partners
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