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PLCG1 and NPM1
Data Source:
BioGRID
(pull down, affinity chromatography technology)
PLCG1
NPM1
Description
phospholipase C gamma 1
nucleophosmin 1
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Lamellipodium
Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Focal Adhesion
Membrane
Spindle Pole Centrosome
Protein-containing Complex
Protein-DNA Complex
Ribonucleoprotein Complex
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Glutamate Receptor Binding
Calcium-dependent Phospholipase C Activity
Core Promoter Sequence-specific DNA Binding
Chromatin Binding
Transcription Coactivator Activity
RNA Binding
Protein Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Tat Protein Binding
Activating Transcription Factor Binding
Histone Binding
Protein Homodimerization Activity
Ribosomal Large Subunit Binding
Ribosomal Small Subunit Binding
NF-kappaB Binding
Unfolded Protein Binding
Biological Process
In Utero Embryonic Development
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Axon Guidance
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Phospholipase C Activity
Viral Process
Cell Migration
Calcium-mediated Signaling
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Inositol Phosphate Metabolic Process
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
DNA Repair
Nucleosome Assembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
RRNA Export From Nucleus
Intracellular Protein Transport
Nucleocytoplasmic Transport
Centrosome Cycle
Signal Transduction
Cell Aging
Protein Localization
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Centrosome Duplication
Negative Regulation Of Centrosome Duplication
Viral Process
Regulation Of Endodeoxyribonuclease Activity
CENP-A Containing Nucleosome Assembly
Cellular Response To UV
Ribosome Assembly
Ribosomal Large Subunit Biogenesis
Ribosomal Small Subunit Biogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Centriole Replication
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Endoribonuclease Activity
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Regulation Of MRNA Stability Involved In Cellular Response To UV
Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 point mutants in cancer
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Nuclear import of Rev protein
Nuclear import of Rev protein
SUMOylation of transcription cofactors
Deposition of new CENPA-containing nucleosomes at the centromere
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
Artenimol
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Brain morphology (MOSTest) (
32665545
)
Height (
28552196
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
111 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
62 interacting genes:
ABCC1
ACY1
ALK
APP
ARF1
CACYBP
CD24
CDK1
CDK2
CDKN2A
CDT1
CENPW
CLK1
COX8A
CSNK2A1
DUX4
EIF2AK2
ELF4
EP300
ERG
ESR1
FBXW7
GADD45A
GNAI2
GNL3
GRB2
GZMM
H2AC20
H2BC21
H3-4
HAND2
HMGA1
HMGA2
HOXA7
IRF1
IRS1
LINC01554
MDM2
NCL
NOP2
NPM2
PADI4
PARP1
PLCG1
PLCG2
PLK1
PSMC4
RELA
RPGR
SENP3
SHC1
SP1
SREK1
SUMO2
TCERG1
TFAP2A
TP53
TRIM28
UBC
UQCRH
XPO1
YY1
Entrez ID
5335
4869
HPRD ID
01398
01246
Ensembl ID
ENSG00000124181
ENSG00000181163
Uniprot IDs
P19174
Q4LE43
Q9UFY1
A0A0S2Z491
A0A0S2Z4G7
A0A140VJQ2
P06748
PDB IDs
1HSQ
2HSP
4EY0
4FBN
2LLH
2P1B
2VXD
5EHD
Enriched GO Terms of Interacting Partners
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