TRIM14 and KIF3A

Data Source:
BioGRID (two hybrid)

		TRIM14	KIF3A
Description		tripartite motif containing 14	kinesin family member 3A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle	Centrosome Centriole Cytosol Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Kinesin II Complex Extracellular Exosome Ciliary Tip Axon Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Protein Phosphatase Binding Spectrin Binding Small GTPase Binding
	Biological Process	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Organelle Organization Microtubule-based Movement Anterograde Axonal Transport Centriole-centriole Cohesion Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Microtubule Anchoring At Centrosome Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Cell Junction
Pathways		Interferon gamma signaling	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Hedgehog 'off' state Intraflagellar transport Activation of SMO Activation of SMO COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31959851 31619474) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 25574825 22197932 26482879) Atopic march ( 26542096) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Refractive error ( 32231278)
Interacting Genes		84 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	15 interacting genes: APP DISC1 GRB2 KIF3B KIF3C LIG4 MAP3K10 MAP3K11 NEK1 PLEKHA5 PPP1R15A RPGR TRIM14 TULP3 VHL
Entrez ID		9830	11127
HPRD ID		05948	05250
Ensembl ID		ENSG00000106785	ENSG00000131437
Uniprot IDs		A0A024R165 Q14142	B4DHG8 E9PES4 J3KPF9 Q05CT3 Q9Y496
PDB IDs		6JBM
Enriched GO Terms of Interacting Partners?
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