ZFYVE9 and EIF4G1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZFYVE9	EIF4G1
Description		zinc finger FYVE-type containing 9	eukaryotic translation initiation factor 4 gamma 1
Image
GO Annotations	Cellular Component	Early Endosome Cytosol Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Polysome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Protein Domain Specific Binding Metal Ion Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Endosomal Transport	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Death Viral Process Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of MRNA Stability Positive Regulation Of Neuron Differentiation Regulation Of Gene Silencing By MiRNA Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neuron Death Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly Positive Regulation Of MRNA Cap Binding Positive Regulation Of MiRNA Mediated Inhibition Of Translation Regulation Of Polysome Binding
Pathways			ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)
Interacting Genes		38 interacting genes: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBIN ETS2 FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPART ST7 SUMF2 SUPT5H SVEP1 TENT5A TGFBR1 TGFBR2 UBC UBXN11 ZMYND8	40 interacting genes: A1CF ANXA5 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9
Entrez ID		9372	1981
HPRD ID		04782	06774
Ensembl ID		ENSG00000157077	ENSG00000114867
Uniprot IDs		O95405	B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65
PDB IDs		1DEV 1MK2 4BKW 5MJY	1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 6ZMW
Enriched GO Terms of Interacting Partners?
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