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EIF4G1 and EIF4A1
Data Source:
HPRD
(in vivo, in vitro)
EIF4G1
EIF4A1
Description
eukaryotic translation initiation factor 4 gamma 1
eukaryotic translation initiation factor 4A1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Polysome
Cytoplasmic Stress Granule
Membrane
Eukaryotic Translation Initiation Factor 4F Complex
Nucleus
Cytoplasm
Cytosol
Membrane
Eukaryotic Translation Initiation Factor 4F Complex
Extracellular Exosome
Molecular Function
RNA Binding
MRNA Binding
Translation Initiation Factor Activity
Protein Binding
ATP Binding
Translation Factor Activity, RNA Binding
Eukaryotic Initiation Factor 4E Binding
Translation Initiation Factor Binding
Identical Protein Binding
Molecular Adaptor Activity
RNA Cap Binding
RNA Binding
RNA Helicase Activity
Double-stranded RNA Binding
MRNA Binding
Translation Initiation Factor Activity
Helicase Activity
Protein Binding
ATP Binding
Translation Factor Activity, RNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Behavioral Fear Response
Cap-dependent Translational Initiation
Translation
Translational Initiation
Regulation Of Translational Initiation
Negative Regulation Of Autophagy
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Cell Death
Viral Process
Positive Regulation Of Cell Growth
Cellular Response To Nutrient Levels
Positive Regulation Of Cellular Protein Metabolic Process
Developmental Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Regulation Of MRNA Stability
Positive Regulation Of Neuron Differentiation
Regulation Of Gene Silencing By MiRNA
Regulation Of Cellular Response To Stress
Energy Homeostasis
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Neuron Death
Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly
Regulation Of Presynapse Assembly
Positive Regulation Of MRNA Cap Binding
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Regulation Of Polysome Binding
Cytoplasmic Translational Initiation
Translational Initiation
Viral Process
Pathways
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
mTORC1-mediated signalling
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Copper
Diseases
GWAS
Menarche (age at onset) (
25231870
)
Red blood cell count (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
40 interacting genes:
A1CF
ANXA5
ATPAF2
CCDC57
CDKN2D
CENPU
CIB1
CTBP2
DTX2
EIF1
EIF3A
EIF3B
EIF3I
EIF4A1
EIF4A2
EIF4E
EIF5
ENKD1
FXR2
GK
HSPB1
HTRA2
KRT31
KRT34
MKNK1
MKNK2
NCBP1
NCBP2
NTAQ1
PABPC1
PAK2
PDCD4
PEF1
SMARCD1
SRPK2
SUMO2
TRAF2
UBE3A
UPF2
ZFYVE9
13 interacting genes:
EIF4G1
EIF4G2
EIF4G3
FAM107A
LIG4
MAPK6
PAIP1
PLPPR4
PRMT1
SUMO2
TNKS
UCHL5
UPF2
Entrez ID
1981
1973
HPRD ID
06774
04030
Ensembl ID
ENSG00000114867
ENSG00000161960
Uniprot IDs
B2RU06
B2RU10
B4DSI9
O95065
Q04637
Q96I65
P60842
PDB IDs
1LJ2
1UG3
2W97
4AZA
4F02
5EHC
5EI3
5EIR
5T46
6ZMW
2G9N
2ZU6
3EIQ
5ZBZ
5ZC9
6ZMW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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