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EIF4G1 and NCBP1
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
EIF4G1
NCBP1
Description
eukaryotic translation initiation factor 4 gamma 1
nuclear cap binding protein subunit 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Polysome
Cytoplasmic Stress Granule
Membrane
Eukaryotic Translation Initiation Factor 4F Complex
Nucleus
Nucleoplasm
Mitochondrion
Cytosol
MRNA Cap Binding Complex
Nuclear Cap Binding Complex
RNA Cap Binding Complex
Ribonucleoprotein Complex
Molecular Function
RNA Binding
MRNA Binding
Translation Initiation Factor Activity
Protein Binding
ATP Binding
Translation Factor Activity, RNA Binding
Eukaryotic Initiation Factor 4E Binding
Translation Initiation Factor Binding
Identical Protein Binding
Molecular Adaptor Activity
RNA Cap Binding
RNA 7-methylguanosine Cap Binding
RNA Binding
MRNA Binding
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Behavioral Fear Response
Cap-dependent Translational Initiation
Translation
Translational Initiation
Regulation Of Translational Initiation
Negative Regulation Of Autophagy
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Cell Death
Viral Process
Positive Regulation Of Cell Growth
Cellular Response To Nutrient Levels
Positive Regulation Of Cellular Protein Metabolic Process
Developmental Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Regulation Of MRNA Stability
Positive Regulation Of Neuron Differentiation
Regulation Of Gene Silencing By MiRNA
Regulation Of Cellular Response To Stress
Energy Homeostasis
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Neuron Death
Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly
Regulation Of Presynapse Assembly
Positive Regulation Of MRNA Cap Binding
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Regulation Of Polysome Binding
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Spliceosomal Complex Assembly
MRNA Splicing, Via Spliceosome
Transcription By RNA Polymerase II
Transcription Elongation From RNA Polymerase II Promoter
Termination Of RNA Polymerase II Transcription
7-methylguanosine MRNA Capping
RNA Catabolic Process
RNA Export From Nucleus
MRNA Export From Nucleus
Regulation Of Translational Initiation
Histone MRNA Metabolic Process
RNA Splicing
Fibroblast Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Positive Regulation Of Cell Growth
Gene Silencing By RNA
MRNA 3'-end Processing
Positive Regulation Of MRNA 3'-end Processing
SnRNA Transcription By RNA Polymerase II
MRNA Cis Splicing, Via Spliceosome
Positive Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of MRNA Processing
Nuclear Export
Pre-mRNA Cleavage Required For Polyadenylation
Regulation Of MRNA Polyadenylation
Positive Regulation Of RNA Binding
Pathways
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
mTORC1-mediated signalling
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SLBP independent Processing of Histone Pre-mRNAs
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Abortive elongation of HIV-1 transcript in the absence of Tat
snRNP Assembly
RNA Polymerase II Pre-transcription Events
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3'-end processing
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription Termination
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Processing of Intronless Pre-mRNAs
Signaling by FGFR2 IIIa TM
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Menarche (age at onset) (
25231870
)
Red blood cell count (
32888494
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Interacting Genes
40 interacting genes:
A1CF
ANXA5
ATPAF2
CCDC57
CDKN2D
CENPU
CIB1
CTBP2
DTX2
EIF1
EIF3A
EIF3B
EIF3I
EIF4A1
EIF4A2
EIF4E
EIF5
ENKD1
FXR2
GK
HSPB1
HTRA2
KRT31
KRT34
MKNK1
MKNK2
NCBP1
NCBP2
NTAQ1
PABPC1
PAK2
PDCD4
PEF1
SMARCD1
SRPK2
SUMO2
TRAF2
UBE3A
UPF2
ZFYVE9
18 interacting genes:
BNIP1
BNIP2
BNIP3
EIF4G1
EIF4G2
HNRNPF
HNRNPH1
LINC01554
NCBP2
NCBP3
PSTPIP1
PTEN
RNF20
RNF40
RPS6KB1
SNRPA1
STAU1
ZDHHC17
Entrez ID
1981
4686
HPRD ID
06774
02717
Ensembl ID
ENSG00000114867
ENSG00000136937
Uniprot IDs
B2RU06
B2RU10
B4DSI9
O95065
Q04637
Q96I65
A0A024R179
Q09161
PDB IDs
1LJ2
1UG3
2W97
4AZA
4F02
5EHC
5EI3
5EIR
5T46
6ZMW
1H2T
1H2U
1H2V
1H6K
1N52
1N54
3FEX
3FEY
5OO6
5OOB
6D0Y
Enriched GO Terms of Interacting Partners
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