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EIF4G1 and ENKD1
Data Source:
BioGRID
(two hybrid)
EIF4G1
ENKD1
Description
eukaryotic translation initiation factor 4 gamma 1
enkurin domain containing 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Polysome
Cytoplasmic Stress Granule
Membrane
Eukaryotic Translation Initiation Factor 4F Complex
Cytoplasmic Microtubule
Microtubule Cytoskeleton
Ciliary Base
Molecular Function
RNA Binding
MRNA Binding
Translation Initiation Factor Activity
Protein Binding
ATP Binding
Translation Factor Activity, RNA Binding
Eukaryotic Initiation Factor 4E Binding
Translation Initiation Factor Binding
Identical Protein Binding
Molecular Adaptor Activity
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Behavioral Fear Response
Cap-dependent Translational Initiation
Translation
Translational Initiation
Regulation Of Translational Initiation
Negative Regulation Of Autophagy
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Cell Death
Viral Process
Positive Regulation Of Cell Growth
Cellular Response To Nutrient Levels
Positive Regulation Of Cellular Protein Metabolic Process
Developmental Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Regulation Of MRNA Stability
Positive Regulation Of Neuron Differentiation
Regulation Of Gene Silencing By MiRNA
Regulation Of Cellular Response To Stress
Energy Homeostasis
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Neuron Death
Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly
Regulation Of Presynapse Assembly
Positive Regulation Of MRNA Cap Binding
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Regulation Of Polysome Binding
Pathways
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
mTORC1-mediated signalling
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Menarche (age at onset) (
25231870
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
40 interacting genes:
A1CF
ANXA5
ATPAF2
CCDC57
CDKN2D
CENPU
CIB1
CTBP2
DTX2
EIF1
EIF3A
EIF3B
EIF3I
EIF4A1
EIF4A2
EIF4E
EIF5
ENKD1
FXR2
GK
HSPB1
HTRA2
KRT31
KRT34
MKNK1
MKNK2
NCBP1
NCBP2
NTAQ1
PABPC1
PAK2
PDCD4
PEF1
SMARCD1
SRPK2
SUMO2
TRAF2
UBE3A
UPF2
ZFYVE9
207 interacting genes:
ABI1
ABI2
ACOT7
AKAP8L
ANKRD23
ANKRD49
APP
ARMC5
ASB3
AVPI1
BANP
BCAS2
BCAS4
BCAT1
BEGAIN
BEX3
BHLHB9
BLZF1
BRAT1
C18orf54
C19orf54
C1orf105
CALCOCO1
CALCOCO2
CBY1
CBY2
CCDC102B
CCDC13
CCDC136
CCDC28B
CCDC85B
CDCA4
CDPF1
CDR2
CDSN
CEP55
CEP70
CHCHD3
CHRDL2
COA7
CTBP2
CYSRT1
DGCR6
DVL2
DVL3
DYDC1
ECM1
EFHC2
EIF4G1
EYA2
EZHIP
FAM102A
FAM228A
FAM90A1
FCHSD2
FKBP6
FOS
FOSB
FSD2
GADD45G
GADD45GIP1
GET4
GFAP
GIGYF1
GOLGA2
GOLGA6A
GOLGA6L9
GRHL3
GRIPAP1
HMBOX1
HNRNPH1
HOMEZ
HOOK2
HOXA1
HSF2BP
HSPB2
HSPB2-C11orf52
ID2
IGF1
IGFBP6
IKBKG
IKZF3
JAKMIP1
KIFC3
KLHL20
KLHL26
KRT14
KRT15
KRT31
KRT35
KRT40
KRTAP10-5
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP19-1
KRTAP19-5
KRTAP19-6
KRTAP4-11
KRTAP5-9
KRTAP6-2
LDOC1
LHX3
LIN7B
LMO2
LRRC61
LZTS1
MAPK9
MATN4
MDFI
MEIS3
MESD
METTL27
MID2
MIF4GD
MIPOL1
MISP
MKRN3
MLH1
MORN3
MORN5
MRNIP
MRPL28
MRPL38
MTUS2
MYF5
MYOZ3
N4BP3
NAB2
NBPF22P
NBPF6
NCKIPSD
NDUFB7
NEFL
NFKBIA
NHLRC4
NUTM1
OOEP
PAK5
PDLIM7
PDZD4
PHC2
PIBF1
PICK1
PIK3R3
PKNOX2
PLSCR1
PNMA1
PNMA2
POLR3C
PPP1CC
PPP2R3C
PRDM14
PRDM6
RAD54B
RBCK1
RBM11
RBPMS
RCN1
RUBCN
RUNDC3A
SLC15A2
SNRNP48
SORBS3
SPAG5
SPDEF
SPSB3
SRGAP3
SSC4D
STAC3
STXBP4
TENT5B
TNNI1
TNS2
TOX2
TRAF1
TRAF2
TRAK1
TRGV7
TRIM23
TRIM27
TRIM35
TRIM54
TSC1
TSC22D4
TSEN15
UBXN11
USH1C
USH1G
USHBP1
USP20
VBP1
VPS37B
VWC2
WDR62
WWOX
YWHAE
ZBTB14
ZC2HC1C
ZFP90
ZNF143
ZNF426
ZNF511
ZNF581
ZNF76
ZRANB1
Entrez ID
1981
84080
HPRD ID
06774
13151
Ensembl ID
ENSG00000114867
ENSG00000124074
Uniprot IDs
B2RU06
B2RU10
B4DSI9
O95065
Q04637
Q96I65
Q9H0I2
PDB IDs
1LJ2
1UG3
2W97
4AZA
4F02
5EHC
5EI3
5EIR
5T46
6ZMW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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