EIF4G1 and PDCD4

Data Source:
HPRD (in vitro)

		EIF4G1	PDCD4
Description		eukaryotic translation initiation factor 4 gamma 1	programmed cell death 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Identical Protein Binding Molecular Adaptor Activity	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Death Viral Process Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of MRNA Stability Positive Regulation Of Neuron Differentiation Regulation Of Gene Silencing By MiRNA Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neuron Death Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly Positive Regulation Of MRNA Cap Binding Positive Regulation Of MiRNA Mediated Inhibition Of Translation Regulation Of Polysome Binding	Apoptotic Process Cell Aging BMP Signaling Pathway Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)	Fish- and plant-related diet ( 32066663)
Interacting Genes		40 interacting genes: A1CF ANXA5 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9	16 interacting genes: APOE BTRC CSNK2A1 EIF4A2 EIF4A3 EIF4G1 IBTK LRRK1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2 SUMO2
Entrez ID		1981	27250
HPRD ID		06774	10549
Ensembl ID		ENSG00000114867	ENSG00000150593
Uniprot IDs		B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65	B4DKX4 Q53EL6
PDB IDs		1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 6ZMW	2GGF 2KZT 2RG8 2ZU6 3EIJ
Enriched GO Terms of Interacting Partners?
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