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RNF8 and EPN2
Data Source:
BioGRID
(two hybrid)
RNF8
EPN2
Description
ring finger protein 8
epsin 2
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytosol
Midbody
Site Of Double-strand Break
Endosome
Cytosol
Plasma Membrane
Clathrin Vesicle Coat
Clathrin Coat Of Endocytic Vesicle
Intracellular Membrane-bounded Organelle
Molecular Function
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Phospholipid Binding
Clathrin Binding
Cadherin Binding
Biological Process
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Cell Cycle
Spermatid Development
Response To Ionizing Radiation
Viral Process
Protein Ubiquitination
Histone H2A Ubiquitination
Histone H2B Ubiquitination
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Spermatogenesis, Exchange Of Chromosomal Proteins
Interstrand Cross-link Repair
Histone Exchange
Isotype Switching
Positive Regulation Of DNA Repair
Cell Division
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Histone H2A K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Endocytosis
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Notch Signaling Pathway
Membrane Organization
Negative Regulation Of Sprouting Angiogenesis
Pathways
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Diseases
GWAS
Acne (severe) (
24927181
)
Restless legs syndrome (
29029846
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Diastolic blood pressure (
30224653
)
White matter hyperintensities (
32358547
)
Interacting Genes
76 interacting genes:
AMOTL2
BLM
C2CD6
CALCOCO1
CCDC14
CCDC50
CCDC85B
CEP44
CEP85
CHD4
CHEK2
CLK2
CLK3
DNM2
DNTTIP2
EPN2
EPN3
EXOSC2
FAM9B
FSD2
GPRASP2
H2AC20
H2AX
H2BC21
H2BC3
H3-3B
HOMEZ
JMJD1C
KDM4A
KIF24
KRTAP10-1
KRTAP10-8
KRTAP9-2
KRTAP9-8
LMO4
MAD1L1
MAGED1
MAPK1
MDC1
MDM2
PCNA
PCYT1A
PGRMC2
PICK1
PNMA2
POLD4
PSMB1
RBFOX2
RXRA
RYBP
SCN3B
SEPTIN3
SH3GL3
STX11
SUMO2
SUMO3
TMEM79
TNIP1
TOMM20L
TRIM29
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2V2
UBE2W
VCP
WASL
YEATS4
ZBTB10
ZNF346
ZNF496
40 interacting genes:
APOE
ARRDC1
ARRDC2
ARRDC3
ATXN1
CDIP1
CLTC
DAZAP2
EIF3E
EPS15
FAIM2
FAM168A
FANCM
ITSN1
LAPTM5
LITAF
MID1
MID2
MLANA
PIP4P1
PLEKHB2
PMEPA1
PRKAA2
RNF11
RNF8
SMAD1
SPART
TFAP2A
THOP1
TRIM23
TRIM26
TRIM62
TUBA1B
TXLNA
UBA52
UBC
WBP1
WBP1L
WBP2
YWHAG
Entrez ID
9025
22905
HPRD ID
11521
06271
Ensembl ID
ENSG00000112130
ENSG00000072134
Uniprot IDs
O76064
O95208
PDB IDs
2CSW
2PIE
4AYC
4ORH
4WHV
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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