EPN2 and THOP1

Data Source:
BioGRID (two hybrid)

		EPN2	THOP1
Description		epsin 2	thimet oligopeptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin Coat Of Endocytic Vesicle Intracellular Membrane-bounded Organelle	Mitochondrial Intermembrane Space Cytosol
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding Cadherin Binding	Metalloendopeptidase Activity Protein Binding Peptide Binding Metal Ion Binding
	Biological Process	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Protein Polyubiquitination Proteolysis Peptide Metabolic Process
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547)	Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 32888494) Plateletcrit ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		40 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 SMAD1 SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG	9 interacting genes: AGTR1 CALM1 EPN2 LINC01554 MPHOSPH6 PALS2 PRKACA STK11 TRAF2
Entrez ID		22905	7064
HPRD ID		06271	03072
Ensembl ID		ENSG00000072134	ENSG00000172009
Uniprot IDs		O95208	P52888
PDB IDs			1S4B 2O36
Enriched GO Terms of Interacting Partners?
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