EPN2 and PIP4P1

Data Source:
BioGRID (two hybrid)

		EPN2	PIP4P1
Description		epsin 2	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin Coat Of Endocytic Vesicle Intracellular Membrane-bounded Organelle	Nucleoplasm Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Late Endosome Membrane
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding Cadherin Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity
	Biological Process	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Phospholipid Metabolic Process Response To Sterol Depletion Cholesterol Metabolic Process Lysosome Localization Phosphatidylinositol Dephosphorylation Proton-transporting V-type ATPase Complex Assembly Positive Regulation Of TORC1 Signaling
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	PI5P Regulates TP53 Acetylation Synthesis of PIPs in the nucleus
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547)
Interacting Genes		40 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 SMAD1 SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG	4 interacting genes: EPN2 PLEKHB2 RILPL1 SLC10A6
Entrez ID		22905	90809
HPRD ID		06271	12660
Ensembl ID		ENSG00000072134	ENSG00000165782
Uniprot IDs		O95208	Q86T03
PDB IDs
Enriched GO Terms of Interacting Partners?
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