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RNF8 and CHD4
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)
RNF8
CHD4
Description
ring finger protein 8
chromodomain helicase DNA binding protein 4
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytosol
Midbody
Site Of Double-strand Break
Chromatin
Nucleoplasm
Cytoplasm
Centrosome
Membrane
NuRD Complex
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
DNA Helicase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Zinc Ion Binding
Nucleosomal DNA Binding
Histone Deacetylase Binding
Biological Process
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Cell Cycle
Spermatid Development
Response To Ionizing Radiation
Viral Process
Protein Ubiquitination
Histone H2A Ubiquitination
Histone H2B Ubiquitination
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Spermatogenesis, Exchange Of Chromosomal Proteins
Interstrand Cross-link Repair
Histone Exchange
Isotype Switching
Positive Regulation Of DNA Repair
Cell Division
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Histone H2A K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Transcription By RNA Polymerase II
DNA Duplex Unwinding
ATP-dependent Chromatin Remodeling
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
NGF-stimulated transcription
Potential therapeutics for SARS
Drugs
Diseases
GWAS
Acne (severe) (
24927181
)
Restless legs syndrome (
29029846
)
Heel bone mineral density (
30598549
)
Mean spheric corpuscular volume (
32888494
)
Myopia (pathological) (
23049088
)
Interacting Genes
76 interacting genes:
AMOTL2
BLM
C2CD6
CALCOCO1
CCDC14
CCDC50
CCDC85B
CEP44
CEP85
CHD4
CHEK2
CLK2
CLK3
DNM2
DNTTIP2
EPN2
EPN3
EXOSC2
FAM9B
FSD2
GPRASP2
H2AC20
H2AX
H2BC21
H2BC3
H3-3B
HOMEZ
JMJD1C
KDM4A
KIF24
KRTAP10-1
KRTAP10-8
KRTAP9-2
KRTAP9-8
LMO4
MAD1L1
MAGED1
MAPK1
MDC1
MDM2
PCNA
PCYT1A
PGRMC2
PICK1
PNMA2
POLD4
PSMB1
RBFOX2
RXRA
RYBP
SCN3B
SEPTIN3
SH3GL3
STX11
SUMO2
SUMO3
TMEM79
TNIP1
TOMM20L
TRIM29
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2V2
UBE2W
VCP
WASL
YEATS4
ZBTB10
ZNF346
ZNF496
21 interacting genes:
ATM
ATR
CSNK2A1
EP300
H3-4
H3C1
HDAC1
IKZF4
MBD3L2
MTNR1A
PSTPIP1
PTEN
RNF8
RORC
SMARCA4
SUMO2
TRIM27
TTN
TWIST1
UBE2I
XRN1
Entrez ID
9025
1108
HPRD ID
11521
04472
Ensembl ID
ENSG00000112130
ENSG00000111642
Uniprot IDs
O76064
F5GWX5
Q14839
PDB IDs
2CSW
2PIE
4AYC
4ORH
4WHV
1MM2
1MM3
2EE1
2L5U
2L75
2N5N
4O9I
6BGG
6Q3M
6RYR
6RYU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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