EPN2 and SPART

Data Source:
BioGRID (two hybrid)

		EPN2	SPART
Description		epsin 2	spartin
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin Coat Of Endocytic Vesicle Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding Cadherin Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547)
Interacting Genes		40 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 SMAD1 SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG	22 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9
Entrez ID		22905	23111
HPRD ID		06271	06170
Ensembl ID		ENSG00000072134	ENSG00000133104
Uniprot IDs		O95208	A0A024RDV9 Q8N0X7
PDB IDs			2DL1 4U7I
Enriched GO Terms of Interacting Partners?
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