Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
RNF8 and SUMO2
Data Source:
BioGRID
(two hybrid, pull down, affinity chromatography technology, imaging technique)
RNF8
SUMO2
Description
ring finger protein 8
small ubiquitin like modifier 2
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytosol
Midbody
Site Of Double-strand Break
Nucleus
Nucleoplasm
PML Body
Molecular Function
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Binding
Ubiquitin Protein Ligase Activity
RNA Binding
Protein Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Ubiquitin-like Protein Ligase Binding
Biological Process
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Cell Cycle
Spermatid Development
Response To Ionizing Radiation
Viral Process
Protein Ubiquitination
Histone H2A Ubiquitination
Histone H2B Ubiquitination
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Spermatogenesis, Exchange Of Chromosomal Proteins
Interstrand Cross-link Repair
Histone Exchange
Isotype Switching
Positive Regulation Of DNA Repair
Cell Division
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Histone H2A K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein Sumoylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Vitamin D (calciferol) metabolism
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS
Acne (severe) (
24927181
)
Restless legs syndrome (
29029846
)
Deep white matter hyperintensities (
32517579
)
Gamma glutamyl transferase levels (
29403010
)
Type 2 diabetes (
32499647
)
Interacting Genes
76 interacting genes:
AMOTL2
BLM
C2CD6
CALCOCO1
CCDC14
CCDC50
CCDC85B
CEP44
CEP85
CHD4
CHEK2
CLK2
CLK3
DNM2
DNTTIP2
EPN2
EPN3
EXOSC2
FAM9B
FSD2
GPRASP2
H2AC20
H2AX
H2BC21
H2BC3
H3-3B
HOMEZ
JMJD1C
KDM4A
KIF24
KRTAP10-1
KRTAP10-8
KRTAP9-2
KRTAP9-8
LMO4
MAD1L1
MAGED1
MAPK1
MDC1
MDM2
PCNA
PCYT1A
PGRMC2
PICK1
PNMA2
POLD4
PSMB1
RBFOX2
RXRA
RYBP
SCN3B
SEPTIN3
SH3GL3
STX11
SUMO2
SUMO3
TMEM79
TNIP1
TOMM20L
TRIM29
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2V2
UBE2W
VCP
WASL
YEATS4
ZBTB10
ZNF346
ZNF496
454 interacting genes:
AARS1
ABCF1
ABRAXAS1
ACIN1
ACTB
AHCYL1
AHNAK
AHNAK2
AIMP1
ALAS1
ANAPC1
ANAPC2
ANLN
ANXA1
APRT
ARF3
ARF4
ARID2
ASNS
ASS1
ATF7IP
ATRX
ATXN7
BABAM2
BAD
BAZ1A
BAZ1B
BLM
BOD1L1
BPTF
BRCC3
BZW1
C18orf25
CAD
CALM1
CARS1
CAST
CCAR2
CCNE2
CCT2
CCT3
CCT4
CCT5
CCT6A
CDK2
CENPC
CHAF1A
CHAF1B
CHAMP1
CHD3
CHD4
CHD8
CKAP5
CLTC
CMTM6
COPA
COPB2
COPG1
CPSF2
CPSF7
CSE1L
CSNK2B
CTNNBL1
CTNND1
CTR9
CUL3
CUX1
DAB2
DARS1
DAXX
DCD
DDX1
DDX17
DDX21
DDX39A
DDX39B
DDX3X
DDX5
DIDO1
DIP2B
DNAJA1
DNM1L
DNMT1
DYNC1H1
EDC4
EEF1A1
EEF1A2
EEF1G
EEF2
EFTUD2
EGLN3
EHD4
EHMT1
EIF4A1
EIF4A2
EIF4G1
EIF4G2
EIF5A
ELAC2
EME1
EMG1
EML3
ENO1
EP300
EP400
EPPK1
EPRS1
ERCC4
ERCC6
EXOSC10
EXOSC9
EZR
FARSB
FASN
FBXO38
FLNA
FLNB
FOS
GALK1
GAPVD1
GATAD2B
GCN1
GEMIN5
GPATCH8
GTF2I
GTF3C1
GTF3C2
GTF3C4
GYS1
HCFC1
HDAC1
HDAC2
HDAC4
HDAC9
HDLBP
HIPK2
HK2
HMGXB4
HNRNPA0
HNRNPA1L2
HNRNPA2B1
HNRNPF
HNRNPH1
HNRNPH2
HNRNPK
HNRNPL
HNRNPLL
HNRNPM
HNRNPR
HNRNPU
HOMEZ
HP1BP3
HPS6
HSF2
HSP90AA1
HSP90AB1
HSPA1A
HSPA5
HSPA8
HSPA9
HSPB1
HSPD1
HUWE1
IARS1
ILK
IMPDH2
INTS3
IPO5
IQGAP1
JUN
KALRN
KARS1
KDM1A
KDM5C
KIF11
KIF18B
KIF23
KIF2A
KIF2C
KIF4A
KIF5B
KPNA2
KRT8
LARS1
LAS1L
LEF1
LMNA
LMO7
MAF1
MAP4
MARS1
MAST2
MCM3
MCM4
MDC1
MDN1
MKI67
MMS19
MORC3
MPI
MRE11
MSH2
MSH3
MSH6
MSX1
MTA1
MTA2
MTHFD1
MUS81
MYB
MYG1
NAP1L1
NARS1
NAT10
NBN
NCAPD2
NCAPD3
NCAPG
NCAPH2
NCL
NCOR1
NFATC2IP
NFE2L2
NIBAN2
NIPBL
NOL9
NONO
NOP2
NPM1
NSUN2
NUMA1
NUP107
NUP160
NUP214
ORC3
P4HA1
P4HB
PAF1
PALLD
PARN
PARP1
PBRM1
PDCD4
PDCD6IP
PDS5A
PELP1
PFKL
PFKM
PFKP
PGK1
PHF3
PHF5A
PHF8
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PKN2
PLEC
PML
POGZ
POLA1
POLD1
POLR2A
PPP1CC
PPP2R1A
PRC1
PRDX6
PRKDC
PRPF6
PRPF8
PSMC1
PSMC3
PSMC4
PSMC5
PTBP1
RAD21
RAD50
RAD51
RAD54L2
RAN
RANBP2
RANGAP1
RARS1
RBBP4
RBBP7
RCC1
RCOR1
RCOR2
RCOR3
RFC2
RFC4
RFC5
RIF1
RNF111
RNF168
RNF20
RNF213
RNF216
RNF4
RNF8
RPL10
RPL3
RPL4
RPS3
RPS4X
RPS6KA3
RREB1
RRM1
RUVBL1
S100A10
SAE1
SAFB
SAFB2
SAMHD1
SARS1
SART1
SCAF11
SENP1
SENP2
SENP3
SENP5
SENP6
SENP7
SERPINB6
SETDB1
SETX
SF3A1
SF3B1
SF3B2
SIMC1
SIN3A
SIRT1
SLC22A2
SLX4IP
SMARCA4
SMARCAD1
SMC1A
SMC2
SMC3
SMC4
SMCHD1
SND1
SNRNP200
SNW1
SNX27
SOBP
SOX10
SOX6
SP1
SP100
SPATA5
SPATA5L1
SPR
SPTAN1
SPTBN1
SRCAP
SRP68
SRRM2
SRRT
SSRP1
STAG2
STIP1
STRAP
SUPT16H
SUPT5H
SYMPK
SYNCRIP
TAF1
TAGLN2
TCERG1
TCP1
TDG
TDP2
TEAD3
TEX10
TK1
TLN1
TMPO
TNIP1
TOP2A
TOP2B
TOPORS
TP53BP1
TP53BP2
TPR
TPX2
TRAF1
TRIM25
TRIM26
TRIM28
TRIM63
TRIML2
TRIP13
TRMT1L
TSR1
TTI1
TTLL12
TUBA1B
TUBA1C
TUBA4A
TUBB
TUBB4A
TUBB4B
TUBB6
U2AF2
UBA1
UBA2
UBAP2L
UBE2I
UBR4
UIMC1
UMPS
UPF1
USP11
USP25
USP28
USP48
USP5
USP7
USP9X
USPL1
VARS1
VIM
WAPL
WASHC2C
WDHD1
WRN
XAB2
XPNPEP1
XPO1
XPO5
XRCC5
XRCC6
YWHAQ
ZBED1
ZBTB2
ZBTB25
ZBTB33
ZBTB39
ZC3H11A
ZCCHC12
ZCCHC7
ZHX1
ZMAT3
ZMYM2
ZMYM3
ZMYM4
ZMYM5
ZMYND8
ZNF451
ZNF496
ZNF638
Entrez ID
9025
6613
HPRD ID
11521
04332
Ensembl ID
ENSG00000112130
ENSG00000188612
Uniprot IDs
O76064
A0A024R8S3
P61956
PDB IDs
2CSW
2PIE
4AYC
4ORH
4WHV
1WM2
1WM3
1WZ0
1Z5Q
2AWT
2CKH
2D07
2IO0
2IO3
2IYD
2N1W
2N9E
2RPQ
3UIN
3UIO
3ZO5
4BKG
4NPN
5D2M
5ELU
5EQL
5GHB
5GHC
6JXW
6JXX
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?