EPN2 and ARRDC1

Data Source:
BioGRID (two hybrid)

		EPN2	ARRDC1
Description		epsin 2	arrestin domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin Coat Of Endocytic Vesicle Intracellular Membrane-bounded Organelle	Cytoplasm Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding Cadherin Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Ligase-substrate Adaptor Activity Arrestin Family Protein Binding
	Biological Process	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Protein Transport Protein Ubiquitination Negative Regulation Of Notch Signaling Pathway Extracellular Vesicle Biogenesis
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547)	Asthma ( 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433)
Interacting Genes		40 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 SMAD1 SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG	11 interacting genes: APP DAPK1 EPN2 KLHL12 MTDH MTURN PDCD6IP TSG101 UBASH3A WWP1 WWP2
Entrez ID		22905	92714
HPRD ID		06271	12491
Ensembl ID		ENSG00000072134	ENSG00000197070
Uniprot IDs		O95208	Q8N5I2
PDB IDs
Enriched GO Terms of Interacting Partners?
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