RHBDD1 and FBXO25

Data Source:
BioGRID (enzymatic study)

		RHBDD1	FBXO25
Description		rhomboid domain containing 1	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Apoptotic Process Positive Regulation Of Protein Processing Membrane Protein Intracellular Domain Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Spermatid Differentiation Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulmonary function ( 17903307)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		18 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC LPCAT2 LRRK2 MFHAS1 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TMEM42 TMEM86B TMIE	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		84236	26260
HPRD ID		13206	16439
Ensembl ID		ENSG00000144468	ENSG00000147364
Uniprot IDs		Q8TEB9	A0A024QZ88 Q8TCJ0
PDB IDs		5EPP
Enriched GO Terms of Interacting Partners?
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