RHBDD1 and TMIE

Data Source:
BioGRID (two hybrid)

		RHBDD1	TMIE
Description		rhomboid domain containing 1	transmembrane inner ear
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment	Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein Processing Membrane Protein Intracellular Domain Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Spermatid Differentiation Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation	Sensory Perception Of Sound Inner Ear Morphogenesis
Pathways
Drugs
Diseases			Deafness, autosomal recessive
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulmonary function ( 17903307)
Interacting Genes		18 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC LPCAT2 LRRK2 MFHAS1 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TMEM42 TMEM86B TMIE	28 interacting genes: ANKRD28 AQP6 CLRN1 CREB3L1 EBP FAM210B HMOX1 JAGN1 KRT34 KRTAP10-8 KRTAP12-3 MDFI NBPF19 NOTCH2NLA PLPP6 PLPPR2 RHBDD1 SEC22A SLC14A1 SUMO1 TLCD4 TMEM101 TMEM11 TMEM14B TMEM242 TMEM51 TMPPE VAPA
Entrez ID		84236	259236
HPRD ID		13206	06252
Ensembl ID		ENSG00000144468	ENSG00000181585
Uniprot IDs		Q8TEB9	Q8NEW7
PDB IDs		5EPP
Enriched GO Terms of Interacting Partners?
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