RHBDD1 and PLEKHB2

Data Source:
BioGRID (two hybrid)

		RHBDD1	PLEKHB2
Description		rhomboid domain containing 1	pleckstrin homology domain containing B2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment	Integral Component Of Membrane Recycling Endosome Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein Processing Membrane Protein Intracellular Domain Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Spermatid Differentiation Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation	Regulation Of Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulmonary function ( 17903307)
Interacting Genes		18 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC LPCAT2 LRRK2 MFHAS1 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TMEM42 TMEM86B TMIE	49 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A
Entrez ID		84236	55041
HPRD ID		13206	15144
Ensembl ID		ENSG00000144468	ENSG00000115762
Uniprot IDs		Q8TEB9	A0A024QZ35 A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7
PDB IDs		5EPP	3AJ4 3VIA
Enriched GO Terms of Interacting Partners?
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