XRCC5 and POLE

Data Source:
HPRD (in vivo)

		XRCC5	POLE
Description		X-ray repair cross complementing 5	DNA polymerase epsilon, catalytic subunit
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding Enzyme Activator Activity DNA-dependent ATPase Activity Ubiquitin Protein Ligase Binding U3 SnoRNA Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Telomere Maintenance Activation Of Innate Immune Response Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Brain Development Cell Population Proliferation Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Small-subunit Processome Assembly Response To Drug Positive Regulation Of Catalytic Activity Neutrophil Degranulation Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Telomerase Activity Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication Initiation Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS			Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)
Interacting Genes		59 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 DUX4 ELF3 ERCC6 GZMA GZMB HSF1 HSPB1 LIG3 LINC01554 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC PTEN RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A ZRANB1	12 interacting genes: ABHD16A GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 STK19 TOPBP1 XRCC5
Entrez ID		7520	5426
HPRD ID		08935	07177
Ensembl ID		ENSG00000079246	ENSG00000177084
Uniprot IDs		P13010	Q07864
PDB IDs		1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH 6ZH6 6ZHA 6ZHE	5VBN
Enriched GO Terms of Interacting Partners?
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