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POLE and XRCC5
Data Source:
HPRD
(in vivo)
POLE
XRCC5
Description
DNA polymerase epsilon, catalytic subunit
X-ray repair cross complementing 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Epsilon DNA Polymerase Complex
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Molecular Function
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity
4 Iron, 4 Sulfur Cluster Binding
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Enzyme Activator Activity
DNA-dependent ATPase Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication Initiation
Leading Strand Elongation
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
DNA Replication Proofreading
Embryonic Organ Development
Nucleic Acid Phosphodiester Bond Hydrolysis
Telomere Maintenance
Activation Of Innate Immune Response
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Brain Development
Cell Population Proliferation
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Small-subunit Processome Assembly
Response To Drug
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of Telomerase Activity
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Fatty Acid
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Drugs
Cladribine
Diseases
GWAS
Body mass index (
26426971
)
Metabolite levels (
23823483
)
Urate levels in overweight individuals (
25811787
)
Interacting Genes
12 interacting genes:
ABHD16A
GINS4
MDM2
PCNA
POLA1
POLD4
POLE2
POLE4
RAD17
STK19
TOPBP1
XRCC5
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
ZRANB1
Entrez ID
5426
7520
HPRD ID
07177
08935
Ensembl ID
ENSG00000177084
ENSG00000079246
Uniprot IDs
Q07864
P13010
PDB IDs
5VBN
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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