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POLE and GINS4
Data Source:
BioGRID
(pull down)
POLE
GINS4
Description
DNA polymerase epsilon, catalytic subunit
GINS complex subunit 4
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Epsilon DNA Polymerase Complex
GINS Complex
Nucleoplasm
Cytoplasm
CMG Complex
Molecular Function
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity
4 Iron, 4 Sulfur Cluster Binding
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication Initiation
Leading Strand Elongation
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
DNA Replication Proofreading
Embryonic Organ Development
Nucleic Acid Phosphodiester Bond Hydrolysis
Double-strand Break Repair Via Break-induced Replication
Inner Cell Mass Cell Proliferation
DNA Strand Elongation Involved In DNA Replication
Pathways
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
Unwinding of DNA
Unwinding of DNA
Drugs
Cladribine
Diseases
GWAS
Body mass index (
26426971
)
Metabolite levels (
23823483
)
Urate levels in overweight individuals (
25811787
)
Interacting Genes
12 interacting genes:
ABHD16A
GINS4
MDM2
PCNA
POLA1
POLD4
POLE2
POLE4
RAD17
STK19
TOPBP1
XRCC5
17 interacting genes:
BIN3
CDC45
CTNNBIP1
DMAP1
GINS1
GINS2
GINS3
KIF16B
LHX8
MCM2
PBX4
POLA1
POLD1
POLE
PPP1R13B
SIK1
SIK1B
Entrez ID
5426
84296
HPRD ID
07177
11583
Ensembl ID
ENSG00000177084
ENSG00000147536
Uniprot IDs
Q07864
Q9BRT9
PDB IDs
5VBN
2E9X
2EHO
2Q9Q
6XTX
6XTY
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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