XRCC5 and LIG3

Data Source:
BioGRID (affinity chromatography technology, pull down)

		XRCC5	LIG3
Description		X-ray repair cross complementing 5	DNA ligase 3
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex	Nucleoplasm Cytoplasm Mitochondrion DNA Ligase III-XRCC1 Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding Enzyme Activator Activity DNA-dependent ATPase Activity Ubiquitin Protein Ligase Binding U3 SnoRNA Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	Telomere Maintenance Activation Of Innate Immune Response Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Brain Development Cell Population Proliferation Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Small-subunit Processome Assembly Response To Drug Positive Regulation Of Catalytic Activity Neutrophil Degranulation Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Telomerase Activity Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor	Double-strand Break Repair Via Homologous Recombination DNA Ligation Lagging Strand Elongation Transcription-coupled Nucleotide-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			Bleomycin
Diseases
GWAS			Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiographic traits ( 32602732) Night sleep phenotypes ( 27126917) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 19305408 29874175) TPE interval (resting) ( 32386560)
Interacting Genes		59 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 DUX4 ELF3 ERCC6 GZMA GZMB HSF1 HSPB1 LIG3 LINC01554 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC PTEN RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A ZRANB1	8 interacting genes: APP JTB NEIL1 PARP1 TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		7520	3980
HPRD ID		08935	02966
Ensembl ID		ENSG00000079246	ENSG00000005156
Uniprot IDs		P13010	P49916
PDB IDs		1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH 6ZH6 6ZHA 6ZHE	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG
Enriched GO Terms of Interacting Partners?
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