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XRCC5 and HSF1
Data Source:
HPRD
(in vitro)
XRCC5
HSF1
Description
X-ray repair cross complementing 5
heat shock transcription factor 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Kinetochore
Condensed Chromosome Kinetochore
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
PML Body
Perinuclear Region Of Cytoplasm
Nuclear Stress Granule
Mitotic Spindle Pole
Chaperone Complex
Ribonucleoprotein Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Enzyme Activator Activity
DNA-dependent ATPase Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Heat Shock Protein Binding
Chromatin DNA Binding
Identical Protein Binding
Sequence-specific DNA Binding
Protein Self-association
Protein Heterodimerization Activity
Hsp90 Protein Binding
Translation Elongation Factor Binding
STAT Family Protein Binding
Sequence-specific Single Stranded DNA Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Telomere Maintenance
Activation Of Innate Immune Response
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Brain Development
Cell Population Proliferation
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Small-subunit Processome Assembly
Response To Drug
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of Telomerase Activity
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Fatty Acid
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
DNA Repair
Regulation Of Transcription By RNA Polymerase II
MRNA Processing
Defense Response
Response To Nutrient
Positive Regulation Of Cell Population Proliferation
MRNA Transcription
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Response To Activity
Viral Process
Negative Regulation Of Protein-containing Complex Assembly
Response To Testosterone
Cellular Response To Heat
Cellular Response To Unfolded Protein
Cellular Protein-containing Complex Assembly
Cellular Response To Potassium Ion
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
MRNA Transport
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Heat Stress
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Estradiol Stimulus
Cellular Response To Gamma Radiation
Cellular Response To Diamide
Negative Regulation Of Inclusion Body Assembly
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Cellular Response To Heat
Positive Regulation Of MRNA Polyadenylation
Negative Regulation Of Neuron Death
Positive Regulation Of Apoptotic DNA Fragmentation
Cellular Response To Sodium Arsenite
Cellular Response To Angiotensin
Positive Regulation Of Microtubule Binding
Cellular Response To Nitroglycerin
Cellular Response To L-glutamine
Response To Hypobaric Hypoxia
Response To Psychosocial Stress
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Regulation of HSF1-mediated heat shock response
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Aggrephagy
Drugs
Bimoclomol
Diseases
GWAS
Dupuytren's disease (
28886342
)
Interacting Genes
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
ZRANB1
51 interacting genes:
CAMK2A
CDC20
CDK6
CEBPB
CHST10
CREBBP
CSNK2A1
DAXX
DNAJB1
EEF1D
ENO2
FILIP1
FKBP4
FKBP5
GSK3A
GTF2A2
GTF2B
HSBP1
HSF2
HSP90AA1
HSP90AB1
HSPA1A
HSPA8
MAPK1
MAPK3
MAPK8
MAPK9
MAPKAPK2
NCOA6
PIM2
PPID
PRKDC
PTGES3
RALBP1
REPS1
RNF20
SMARCA4
STAT1
STUB1
SUB1
SUMO1
SUMO3
SYMPK
TAF1
TAF7
TAF9
TBP
UBE2I
XRCC5
XRCC6
YWHAE
Entrez ID
7520
3297
HPRD ID
08935
00778
Ensembl ID
ENSG00000079246
ENSG00000185122
Uniprot IDs
P13010
Q00613
PDB IDs
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
2LDU
5D5U
5D5V
5HDG
5HDN
Enriched GO Terms of Interacting Partners
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