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XRCC5 and POLA1
Data Source:
HPRD
(in vivo)
XRCC5
POLA1
Description
X-ray repair cross complementing 5
DNA polymerase alpha 1, catalytic subunit
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytosol
Nuclear Matrix
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Enzyme Activator Activity
DNA-dependent ATPase Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Purine Nucleotide Binding
Pyrimidine Nucleotide Binding
Protein Kinase Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Telomere Maintenance
Activation Of Innate Immune Response
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Brain Development
Cell Population Proliferation
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Small-subunit Processome Assembly
Response To Drug
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of Telomerase Activity
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Fatty Acid
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Regulation Of Type I Interferon Production
Mitotic DNA Replication Initiation
DNA Synthesis Involved In UV-damage Excision Repair
Pathways
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Diseases
GWAS
Mean platelet volume (
32888494
)
Platelet count (
32888494
)
Interacting Genes
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
ZRANB1
20 interacting genes:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
HELB
PARP1
POLA2
POLE
PRIM2
RAD51
RB1
RBMS1
SERPINA3
SMC1A
SUMO2
TP53
XRCC5
Entrez ID
7520
5422
HPRD ID
08935
02416
Ensembl ID
ENSG00000079246
ENSG00000101868
Uniprot IDs
P13010
A6NMQ1
P09884
PDB IDs
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
1K0P
1K18
1N5G
4Q5V
4QCL
4Y97
5EXR
5IUD
6AS7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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