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XRCC5 and PDX1
Data Source:
BioGRID
(affinity chromatography technology, pull down)
XRCC5
PDX1
Description
X-ray repair cross complementing 5
pancreatic and duodenal homeobox 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Nuclear Speck
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Enzyme Activator Activity
DNA-dependent ATPase Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Transcription Factor Binding
Protein-containing Complex Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Telomere Maintenance
Activation Of Innate Immune Response
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Brain Development
Cell Population Proliferation
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Small-subunit Processome Assembly
Response To Drug
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of Telomerase Activity
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Fatty Acid
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Type B Pancreatic Cell Differentiation
Glucose Metabolic Process
Generation Of Precursor Metabolites And Energy
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Smoothened Signaling Pathway
Nitric Oxide Mediated Signal Transduction
Central Nervous System Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Wounding
Animal Organ Morphogenesis
Response To Iron(II) Ion
Response To Chlorate
Animal Organ Senescence
Positive Regulation Of Cell Death
Morphogenesis Of Embryonic Epithelium
Insulin Secretion
Exocrine Pancreas Development
Animal Organ Regeneration
Response To Vitamin
Response To Cytokine
Response To Nicotine
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Drug
Glucose Homeostasis
Response To Leucine
Response To Alkaloid
Positive Regulation Of DNA Binding
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Stem Cell Differentiation
Response To Glucocorticoid
Detection Of Glucose
Transdifferentiation
Response To Fatty Acid
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Regulation of gene expression in beta cells
Regulation of gene expression in early pancreatic precursor cells
Drugs
Diseases
Maturity onset diabetes of the young (MODY)
Pancreatic agenesis
Permanent neonatal diabetes mellitus (PNDM)
GWAS
Acute insulin response (
28490609
)
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Birth weight (
31043758
)
Blood sugar levels (
29403010
)
Body mass index (
26426971
)
Fasting blood glucose (
25631608
22581228
)
Fasting blood glucose (BMI interaction) (
22581228
)
Fasting plasma glucose (
28270201
)
Glycated hemoglobin levels (
28898252
)
Pancreatic cancer (
29422604
26098869
25086665
)
Peak insulin response (
28490609
)
Interacting Genes
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
ZRANB1
13 interacting genes:
ATF3
CREB1
IAPP
MAFA
NEUROD1
PBX1
PCIF1
PRKDC
SLC2A2
SPOP
TCF3
XRCC5
XRCC6
Entrez ID
7520
3651
HPRD ID
08935
02843
Ensembl ID
ENSG00000079246
ENSG00000139515
Uniprot IDs
P13010
P52945
PDB IDs
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
6F8F
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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