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XRCC5 and ZRANB1
Data Source:
BioGRID
(two hybrid)
XRCC5
ZRANB1
Description
X-ray repair cross complementing 5
zinc finger RANBP2-type containing 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Enzyme Activator Activity
DNA-dependent ATPase Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Telomere Maintenance
Activation Of Innate Immune Response
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Brain Development
Cell Population Proliferation
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Small-subunit Processome Assembly
Response To Drug
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of Telomerase Activity
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Fatty Acid
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Cytoskeleton Organization
Wnt Signaling Pathway
Cell Migration
Protein Deubiquitination
Protein Phosphopantetheinylation
Regulation Of Cell Morphogenesis
Positive Regulation Of Wnt Signaling Pathway
Protein K29-linked Deubiquitination
Protein K63-linked Deubiquitination
Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein K33-linked Deubiquitination
Pathways
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Degradation of beta-catenin by the destruction complex
Ovarian tumor domain proteases
Drugs
Diseases
GWAS
Blood urea nitrogen levels (
31152163
)
Creatine kinase levels (
29403010
)
Height (
25429064
31562340
)
Interacting Genes
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
ZRANB1
153 interacting genes:
AKT1
ANKRD11
AP1M1
ARHGEF5
ARRDC2
ARRDC3
BAHD1
BRD1
BYSL
C1orf35
CARD9
CBX7
CBX8
CCDC120
CCDC13
CCDC185
CCDC187
CCNL1
CDC45
CDC5L
CDK18
CDKL3
CNNM3
CORO7
CPNE7
CSNK1A1
CWF19L2
DCX
DDX6
DNAJB13
DTNB
DUSP13
EHHADH
EIF3D
ENKD1
ERF
FAIM
FAM124B
FAM161A
FAM161B
FAM214B
FAM50B
FARS2
FNDC11
GADD45GIP1
GAS2L2
GEM
GLIS2
GPANK1
GPKOW
HOXB5
HOXC8
IL16
INO80B
IP6K3
IQUB
JRK
KANK2
KIF9
KIFC3
LENG1
LMO3
LNX1
MAGEB4
MAGOH
MCRS1
METAP1
METTL21A
MFAP1
MID2
MPPED1
MYEF2
NEK6
NUDT16L1
NUDT21
PBLD
PHF1
PHF19
PKN1
PLEKHN1
PNMA5
POLDIP3
POLL
POLR1C
PPP1R18
PRPF18
PRPF3
PRPF31
PSPC1
QARS1
RAPGEF3
RASAL3
RHOBTB3
RNPS1
SDCBP
SNCA
STAMBPL1
STK19
SUV39H1
SYT17
SYTL4
TBC1D3
TBC1D30
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3K
TCEA2
TCEANC
THAP7
TIE1
TLE5
TNS4
TOLLIP
TRAF3IP3
TRAF4
TRAF6
TRAPPC2
TRAPPC2B
TSGA10IP
TSPYL4
TSTD2
TWIST1
UBASH3A
UBC
UBE2S
USP2
UVRAG
VAV3
VEZF1
WT1
XRCC5
ZBTB24
ZBTB47
ZNF124
ZNF17
ZNF250
ZNF408
ZNF417
ZNF438
ZNF490
ZNF497
ZNF552
ZNF575
ZNF581
ZNF587
ZNF599
ZNF629
ZNF648
ZNF764
ZNF775
ZNF792
ZNF837
Entrez ID
7520
54764
HPRD ID
08935
11738
Ensembl ID
ENSG00000079246
ENSG00000019995
Uniprot IDs
P13010
Q9UGI0
PDB IDs
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
3ZRH
5AF6
Enriched GO Terms of Interacting Partners
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