XRCC5 and ZRANB1

Data Source:
BioGRID (two hybrid)

		XRCC5	ZRANB1
Description		X-ray repair cross complementing 5	zinc finger RANBP2-type containing 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding Enzyme Activator Activity DNA-dependent ATPase Activity Ubiquitin Protein Ligase Binding U3 SnoRNA Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Telomere Maintenance Activation Of Innate Immune Response Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Brain Development Cell Population Proliferation Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Small-subunit Processome Assembly Response To Drug Positive Regulation Of Catalytic Activity Neutrophil Degranulation Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Telomerase Activity Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor	Cytoskeleton Organization Wnt Signaling Pathway Cell Migration Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Cell Morphogenesis Positive Regulation Of Wnt Signaling Pathway Protein K29-linked Deubiquitination Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Deubiquitination
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Degradation of beta-catenin by the destruction complex Ovarian tumor domain proteases
Drugs
Diseases
GWAS			Blood urea nitrogen levels ( 31152163) Creatine kinase levels ( 29403010) Height ( 25429064 31562340)
Interacting Genes		59 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 DUX4 ELF3 ERCC6 GZMA GZMB HSF1 HSPB1 LIG3 LINC01554 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC PTEN RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A ZRANB1	153 interacting genes: AKT1 ANKRD11 AP1M1 ARHGEF5 ARRDC2 ARRDC3 BAHD1 BRD1 BYSL C1orf35 CARD9 CBX7 CBX8 CCDC120 CCDC13 CCDC185 CCDC187 CCNL1 CDC45 CDC5L CDK18 CDKL3 CNNM3 CORO7 CPNE7 CSNK1A1 CWF19L2 DCX DDX6 DNAJB13 DTNB DUSP13 EHHADH EIF3D ENKD1 ERF FAIM FAM124B FAM161A FAM161B FAM214B FAM50B FARS2 FNDC11 GADD45GIP1 GAS2L2 GEM GLIS2 GPANK1 GPKOW HOXB5 HOXC8 IL16 INO80B IP6K3 IQUB JRK KANK2 KIF9 KIFC3 LENG1 LMO3 LNX1 MAGEB4 MAGOH MCRS1 METAP1 METTL21A MFAP1 MID2 MPPED1 MYEF2 NEK6 NUDT16L1 NUDT21 PBLD PHF1 PHF19 PKN1 PLEKHN1 PNMA5 POLDIP3 POLL POLR1C PPP1R18 PRPF18 PRPF3 PRPF31 PSPC1 QARS1 RAPGEF3 RASAL3 RHOBTB3 RNPS1 SDCBP SNCA STAMBPL1 STK19 SUV39H1 SYT17 SYTL4 TBC1D3 TBC1D30 TBC1D3B TBC1D3C TBC1D3G TBC1D3K TCEA2 TCEANC THAP7 TIE1 TLE5 TNS4 TOLLIP TRAF3IP3 TRAF4 TRAF6 TRAPPC2 TRAPPC2B TSGA10IP TSPYL4 TSTD2 TWIST1 UBASH3A UBC UBE2S USP2 UVRAG VAV3 VEZF1 WT1 XRCC5 ZBTB24 ZBTB47 ZNF124 ZNF17 ZNF250 ZNF408 ZNF417 ZNF438 ZNF490 ZNF497 ZNF552 ZNF575 ZNF581 ZNF587 ZNF599 ZNF629 ZNF648 ZNF764 ZNF775 ZNF792 ZNF837
Entrez ID		7520	54764
HPRD ID		08935	11738
Ensembl ID		ENSG00000079246	ENSG00000019995
Uniprot IDs		P13010	Q9UGI0
PDB IDs		1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH 6ZH6 6ZHA 6ZHE	3ZRH 5AF6
Enriched GO Terms of Interacting Partners?
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