POLE and STK19

Data Source:
HPRD (two hybrid)

		POLE	STK19
Description		DNA polymerase epsilon, catalytic subunit	serine/threonine kinase 19
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Nucleus Nuclear Speck
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding	Protein Serine/threonine Kinase Activity ATP Binding Small GTPase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication Initiation Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis	Protein Phosphorylation Positive Regulation Of Ras Protein Signal Transduction
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine
Diseases
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)	Age-related macular degeneration ( 23577725) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Broad depression or schizophrenia ( 30626913) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Disease progression in age-related macular degeneration ( 29346644) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Prostate cancer ( 23535732) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908)
Interacting Genes		12 interacting genes: ABHD16A GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 STK19 TOPBP1 XRCC5	14 interacting genes: BHLHE40 MAB21L3 PFDN5 PICK1 POLE POLR2G PRAME SF3B4 SLC29A1 SP3 TBRG4 TRIM23 VIM ZRANB1
Entrez ID		5426	8859
HPRD ID		07177	07281
Ensembl ID		ENSG00000177084	ENSG00000204344
Uniprot IDs		Q07864	A0A1U9X8L3 P49842
PDB IDs		5VBN
Enriched GO Terms of Interacting Partners?
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