XRCC5 and UCHL3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		XRCC5	UCHL3
Description		X-ray repair cross complementing 5	ubiquitin C-terminal hydrolase L3
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding Enzyme Activator Activity DNA-dependent ATPase Activity Ubiquitin Protein Ligase Binding U3 SnoRNA Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Ubiquitin Binding
	Biological Process	Telomere Maintenance Activation Of Innate Immune Response Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Brain Development Cell Population Proliferation Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Small-subunit Processome Assembly Response To Drug Positive Regulation Of Catalytic Activity Neutrophil Degranulation Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Telomerase Activity Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Protein Catabolic Process Post-translational Protein Modification
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
Drugs
Diseases
GWAS			Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)
Interacting Genes		59 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 DUX4 ELF3 ERCC6 GZMA GZMB HSF1 HSPB1 LIG3 LINC01554 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC PTEN RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A ZRANB1	20 interacting genes: ATM ATXN7L3 CDH1 FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5
Entrez ID		7520	7347
HPRD ID		08935	04367
Ensembl ID		ENSG00000079246	ENSG00000118939
Uniprot IDs		P13010	A0A087WTB8 A0A140VJZ4 P15374
PDB IDs		1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH 6ZH6 6ZHA 6ZHE	1UCH 1XD3 6ISU 6QML
Enriched GO Terms of Interacting Partners?
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