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XRCC5 and UCHL3
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, enzymatic study)
XRCC5
UCHL3
Description
X-ray repair cross complementing 5
ubiquitin C-terminal hydrolase L3
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Enzyme Activator Activity
DNA-dependent ATPase Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Peptidase Activity
NEDD8-specific Protease Activity
Ubiquitin Binding
Biological Process
Telomere Maintenance
Activation Of Innate Immune Response
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Brain Development
Cell Population Proliferation
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Small-subunit Processome Assembly
Response To Drug
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of Telomerase Activity
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Fatty Acid
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Protein Catabolic Process
Post-translational Protein Modification
Pathways
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
UCH proteinases
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Neddylation
Drugs
Diseases
GWAS
Diabetic retinopathy (
23562823
)
Metabolite levels (
23823483
)
Interacting Genes
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
ZRANB1
20 interacting genes:
ATM
ATXN7L3
CDH1
FOXM1
LONRF1
NEDD8
NSG2
PJA1
PLA2G2A
POGK
RAD51
TRIM27
TRIM54
TRIM55
TRIM63
UBE2S
USP15
USP21
USP28
XRCC5
Entrez ID
7520
7347
HPRD ID
08935
04367
Ensembl ID
ENSG00000079246
ENSG00000118939
Uniprot IDs
P13010
A0A087WTB8
A0A140VJZ4
P15374
PDB IDs
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
1UCH
1XD3
6ISU
6QML
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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