ZYX and EVL

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ZYX	EVL
Description		zyxin	Enah/Vasp-like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Phagocytic Vesicle	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	RNA Binding Protein Binding Metal Ion Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Cell-matrix Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Viral Process Stress Fiber Assembly Regulation Of Inflammatory Response Cellular Response To Interferon-gamma	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways			Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs		Artenimol
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 28240269) Monocyte percentage of white cells ( 32888494) White blood cell count (basophil) ( 27863252)	Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		35 interacting genes: ACTN1 ATXN1 BSPRY CASS4 ENAH EVL HIPK3 IMP3 LAP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A QRICH1 RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384 ZNF512B	33 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		7791	51466
HPRD ID		03592	10942
Ensembl ID		ENSG00000159840	ENSG00000196405
Uniprot IDs		Q15942 Q96AF9	A0A024R6K5 Q9UI08
PDB IDs
Enriched GO Terms of Interacting Partners?
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