HIPK2 and SUMO1

Data Source:
BioGRID (pull down, imaging technique)
HPRD (two hybrid, in vivo, in vitro)

		HIPK2	SUMO1
Description		homeodomain interacting protein kinase 2	small ubiquitin like modifier 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body RNA Polymerase II Transcription Regulator Complex	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Nuclear Body PML Body Nuclear Speck Nuclear Membrane Nuclear Stress Granule
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding SMAD Binding Virion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Enzyme Binding Protein Tag Ubiquitin Protein Ligase Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Ligase Binding Ubiquitin-specific Protease Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Positive Regulation Of Protein Phosphorylation Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Process Neuron Differentiation Erythrocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Positive Regulation Of Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Protein Sumoylation Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Action Potential Negative Regulation Of Transcription, DNA-templated Protein Stabilization Roof Of Mouth Development Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression SUMOylation of transcription cofactors Physiological factors Regulation of TP53 Activity through Phosphorylation RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MECP2 expression and activity	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein
Drugs		Fostamatinib
Diseases
GWAS		Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systolic blood pressure ( 28135244)
Interacting Genes		52 interacting genes: AATF ABL1 BTRC CBX3 CHMP4B CREBBP CUL1 CXCL1 DAXX DDX39A DDX39B FBXW7 H2BC21 HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK PARP1 PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SIAH1 SIAH2 SIRT1 SKI SMAD1 SMAD2 SMAD3 SP100 SUMO1 SUMO2 SUMO3 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4	151 interacting genes: AR ATF2 ATXN1 ATXN3 ATXN7 AXIN1 BIRC3 BLM BRCA1 BTBD3 C11orf65 C18orf25 CANX CARD9 CASP2 CASP8 CCR2 CDK6 CHAF1A CHD3 CREBBP DAXX DEUP1 DNM1 DNMT3B DTX2 EDARADD EGLN3 EIF2AK2 ERCC6 ETV6 FAF1 FAM118B FAS FASLG FBF1 FOS FOXM1 GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HNRNPC HNRNPK HSF1 HTT IKZF3 IRAK1 JUN MAPK1IP1L MDM2 MEF2A MITF MRE11 MRTFA MSX1 MTOR MUL1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NFE2L2 NFKBIA NIN NR3C1 NR3C2 PARK7 PAX6 PCNA PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PKM PLAGL1 PML PPM1J PRKN PROP1 PSIP1 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RHOXF2 RNF111 RNF167 RNF4 RPS3 SAE1 SALL1 SATB1 SENP1 SENP2 SENP6 SETX SLC2A1 SOX10 SOX2 SOX6 SP100 SP3 SPOP SREBF1 SREBF2 SUMO1P1 TDG TDP2 TFCP2 TMIE TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF2 TRAF4 TRAF5 TRIM24 TRPS1 TSC22D3 UBA2 UBE2I USP25 USPL1 WRN XPO1 ZBTB16 ZBTB2 ZBTB26 ZBTB6 ZCCHC12 ZCCHC7 ZFP42 ZHX1 ZMYM2 ZMYM3 ZMYM5 ZNF451
Entrez ID		28996	7341
HPRD ID		06039	03554
Ensembl ID		ENSG00000064393	ENSG00000116030
Uniprot IDs		Q9H2X6	A0A024R3Z2 P63165
PDB IDs		6P5S	1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2MW5 2N1A 2N1V 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP 4WJN 4WJO 4WJP 4WJQ 5AEK 5B7A 5ELJ 5GHD 6EOP 6EOT 6J4I 6JXU 6JXV 6K5T 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 6UYX 6UYY 6UYZ 6V7P 6V7Q 6V7R 6V7S 6WW3
Enriched GO Terms of Interacting Partners?
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