Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
XPA and BMPR1A
Data Source:
BioGRID
(two hybrid)
XPA
BMPR1A
Description
XPA, DNA damage recognition and repair factor
bone morphogenetic protein receptor type 1A
Image
GO Annotations
Cellular Component
Nucleotide-excision Repair Factor 1 Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytoplasm
Intercellular Bridge
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Integral Component Of Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
HFE-transferrin Receptor Complex
Molecular Function
Damaged DNA Binding
Protein Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Protein Homodimerization Activity
SMAD Binding
Metal Ion Binding
BMP Receptor Activity
Biological Process
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
UV Protection
Response To Auditory Stimulus
Nucleotide-excision Repair, DNA Incision
Protein Localization To Nucleus
Global Genome Nucleotide-excision Repair
UV-damage Excision Repair
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
In Utero Embryonic Development
Mesoderm Formation
Somitogenesis
Mullerian Duct Regression
Positive Regulation Of Mesenchymal Cell Proliferation
Chondrocyte Differentiation
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Cardiac Conduction System Development
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Endocardial Cushion Formation
Protein Phosphorylation
Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Ectoderm Development
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Neural Crest Cell Development
Negative Regulation Of Smooth Muscle Cell Migration
Stem Cell Population Maintenance
Pituitary Gland Development
Neural Plate Mediolateral Regionalization
Lung Development
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Hindlimb Morphogenesis
Dorsal Aorta Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Structural Organization
Lateral Mesoderm Development
Regulation Of Lateral Mesodermal Cell Fate Specification
Mesendoderm Development
Embryonic Organ Development
Developmental Growth
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Neurogenesis
Roof Of Mouth Development
Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Heart Formation
BMP Signaling Pathway Involved In Heart Development
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Cardiac Ventricle Development
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Fibrous Ring Of Heart Morphogenesis
Regulation Of Neural Crest Cell Differentiation
Regulation Of Cellular Senescence
Pathways
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Signaling by BMP
Drugs
Dibotermin alfa
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Hereditary mixed polyposis syndrome
Juvenile polyposis syndrome
GWAS
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Serum thyroid-stimulating hormone levels (
24852370
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
White blood cell count (
32888494
)
Interacting Genes
51 interacting genes:
ARID3A
ATM
ATR
AURKA
BMPR1A
BUB1
DDB1
DDB2
DLC1
DVL3
ERCC1
ERCC4
ERCC6
FBXW7
GPN1
GTF2E2
GTF2H1
HERC2
MEOX2
MLH1
MLH3
MSH2
MSH3
MUTYH
NDEL1
NRAS
PCNA
PDGFRL
PICK1
PMS2
POLR1C
PRDM16
PRKDC
PSMB1
RASSF1
RB1
RHOU
RPA1
RPA2
RPA4
SKIL
SMAD2
SNPH
SRC
STK11
TBC1D7
TRIM27
VPS26C
XAB2
XPC
ZNF655
45 interacting genes:
ACVR1
ALDOB
AOPEP
BAMBI
BMP2
BMP4
BMP5
BMP6
BMP7
BMPR1B
BMPR2
CDK8
CTSV
FANCC
FBP1
FBP2
FKBP1A
FKBP1B
GALNT12
GDF5
GDF6
GDF9
HOXC8
HRAS
IGFBP3
MAP2K1
MSANTD3
NEDD4
NEDD4L
OTUB1
RASA1
SEC61B
SF3B4
SFRP2
SFRP4
SMAD1
TAB1
TDGF1
TGFB1
TGFBRAP1
TRMO
USP15
XPA
ZMYND11
ZNF189
Entrez ID
7507
657
HPRD ID
02045
03192
Ensembl ID
ENSG00000136936
ENSG00000107779
Uniprot IDs
P23025
P36894
PDB IDs
1D4U
1XPA
2JNW
6J44
6LAE
6RO4
1ES7
1REW
2GOO
2H62
2H64
2K3G
2QJ9
2QJA
2QJB
3NH7
3QB4
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?