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XPA
Description
XPA, DNA damage recognition and repair factor
Image
GO Annotations
Cellular Component
Nucleotide-excision Repair Factor 1 Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytoplasm
Intercellular Bridge
Molecular Function
Damaged DNA Binding
Protein Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
UV Protection
Response To Auditory Stimulus
Nucleotide-excision Repair, DNA Incision
Protein Localization To Nucleus
Global Genome Nucleotide-excision Repair
UV-damage Excision Repair
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Serum thyroid-stimulating hormone levels (
24852370
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Novel Interacting Genes
1 novel interacting genes:
AP2M1
Interacting Genes
51 interacting genes:
ARID3A
ATM
ATR
AURKA
BMPR1A
BUB1
DDB1
DDB2
DLC1
DVL3
ERCC1
ERCC4
ERCC6
FBXW7
GPN1
GTF2E2
GTF2H1
HERC2
MEOX2
MLH1
MLH3
MSH2
MSH3
MUTYH
NDEL1
NRAS
PCNA
PDGFRL
PICK1
PMS2
POLR1C
PRDM16
PRKDC
PSMB1
RASSF1
RB1
RHOU
RPA1
RPA2
RPA4
SKIL
SMAD2
SNPH
SRC
STK11
TBC1D7
TRIM27
VPS26C
XAB2
XPC
ZNF655
Entrez ID
7507
HPRD ID
02045
Ensembl ID
ENSG00000136936
Uniprot IDs
P23025
PDB IDs
1D4U
1XPA
2JNW
6J44
6LAE
6RO4
Enriched GO Terms of Interacting Partners
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