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PSEN1 and FLNA
Data Source:
HPRD
(in vivo, two hybrid)
PSEN1
FLNA
Description
presenilin 1
filamin A
Image
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nucleus
Nuclear Outer Membrane
Nucleoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Synaptic Vesicle
Cell Surface
Membrane
Integral Component Of Membrane
Aggresome
Apical Plasma Membrane
Z Disc
Cell Junction
Growth Cone
Neuromuscular Junction
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Ciliary Rootlet
Azurophil Granule Membrane
Sarcolemma
Neuron Projection
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Gamma-secretase Complex
Integral Component Of Presynaptic Membrane
Extracellular Region
Nucleus
Nucleolus
Cytoplasm
Trans-Golgi Network
Cytosol
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Z Disc
Cortical Cytoskeleton
Myb Complex
Actin Filament Bundle
Dendritic Shaft
Perikaryon
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Apical Dendrite
Postsynapse
Glutamatergic Synapse
Molecular Function
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
PDZ Domain Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Cadherin Binding
ATPase Binding
Growth Factor Receptor Binding
G Protein-coupled Receptor Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Kinase Binding
Small GTPase Binding
Mu-type Opioid Receptor Binding
Fc-gamma Receptor I Complex Binding
Protein Homodimerization Activity
Ion Channel Binding
Cadherin Binding
SMAD Binding
Actin Filament Binding
GTPase Binding
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPKK Activity
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Hematopoietic Progenitor Cell Differentiation
Astrocyte Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
Neural Retina Development
Protein Glycosylation
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Mitochondrial Transport
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Notch Receptor Processing
Learning Or Memory
Memory
Post-embryonic Development
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Neuron Projection Development
Protein Transport
Choline Transport
Synaptic Vesicle Targeting
Protein Processing
Cerebellum Development
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Embryonic Limb Morphogenesis
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Phosphorylation
Positive Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Ephrin Receptor Signaling Pathway
Astrocyte Activation
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Synapse Organization
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Sequestering Of Calcium Ion
Neuron Apoptotic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Resting Membrane Potential
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Dendritic Spine Development
Calcium Ion Transmembrane Transport
Modulation Of Age-related Behavioral Decline
Cell-cell Adhesion
L-glutamate Import Across Plasma Membrane
Cellular Response To Amyloid-beta
Negative Regulation Of Core Promoter Binding
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Positive Regulation Of Amyloid Fibril Formation
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Angiogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Platelet Degranulation
Heart Morphogenesis
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Transcription By RNA Polymerase I
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Platelet Activation
Regulation Of Cell Migration
Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Filament Bundle Assembly
Cell Junction Assembly
Protein Localization To Cell Surface
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Import Into Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of DNA-binding Transcription Factor Activity
Wound Healing, Spreading Of Cells
Early Endosome To Late Endosome Transport
Establishment Of Protein Localization
Cell-cell Junction Organization
Positive Regulation Of Axon Regeneration
Synapse Organization
Protein Stabilization
Cytoplasmic Sequestering Of Protein
Defense Response To Virus
Actin Crosslink Formation
Cilium Assembly
Platelet Aggregation
Semaphorin-plexin Signaling Pathway
Protein Localization To Plasma Membrane
Tubulin Deacetylation
Mitotic Spindle Assembly
Establishment Of Sertoli Cell Barrier
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Potassium Ion Transmembrane Transport
Protein Localization To Bicellular Tight Junction
Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential
Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Integrin-mediated Signaling Pathway
Positive Regulation Of Neuron Migration
Pathways
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Platelet degranulation
GP1b-IX-V activation signalling
Cell-extracellular matrix interactions
RHO GTPases activate PAKs
OAS antiviral response
Drugs
Artenimol
Diseases
Acne inversa; Hidradenitis supprativa
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Alzheimer's disease (AD)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
Periventricular nodular heterotopia (PVNH)
FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS
Apolipoprotein B levels (
32203549
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
98 interacting genes:
ADAMTSL4
APC
AR
ARHGAP24
ARRB1
ARRB2
ASB2
BRCA1
BRCA2
CALCR
CAMK2G
CASR
CAV1
CCNB1
CDC42
CEACAM1
CMIP
DCN
DDIT4L
DRD1
DRD2
DRD3
DUX4
ERBB3
F3
FABP1
FBLIM1
FILIP1
FLNB
FURIN
GP1BA
GRIK1
GRIK3
GRM4
GRM5
GRM7
GRM8
HHLA3
HNRNPD
HSPA6
HSPB7
ITGB1
ITGB3
ITGB5
ITGB6
ITGB7
KCNE4
KCNJ2
KLHL12
LGALS14
LMNA
MAP2K4
MAPK14
MCPH1
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
NLGN3
NPHP1
OPRM1
PAK1
PCBP2
PELO
PHOSPHO2
PLEKHF2
PRKCA
PSEN1
PSEN2
RAC1
RALA
REL
RFLNA
RHOA
SELE
SH2B3
SHBG
SIGLEC10
SIRPA
SMAD3
SMAD5
SPANXD
SRC
SUMO2
SVIL
SYNPO2
TCF4
TLR10
TNIP2
TP73
TRAF2
TRIM55
TRIO
TTN
USP19
VHL
YWHAG
Entrez ID
5663
2316
HPRD ID
00087
02060
Ensembl ID
ENSG00000080815
ENSG00000196924
Uniprot IDs
A0A024R6A3
A0A0S2Z4D2
P49768
P21333
Q60FE5
Q6NXF2
PDB IDs
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
2AAV
2BP3
2BRQ
2J3S
2JF1
2K3T
2K7P
2K7Q
2MTP
2W0P
2WFN
3CNK
3HOC
3HOP
3HOR
3ISW
3RGH
4M9P
4P3W
5XR1
6D8C
6EW1
Enriched GO Terms of Interacting Partners
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