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FLNA and APC
Data Source:
BioGRID
(two hybrid)
FLNA
APC
Description
filamin A
APC regulator of WNT signaling pathway
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleolus
Cytoplasm
Trans-Golgi Network
Cytosol
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Z Disc
Cortical Cytoskeleton
Myb Complex
Actin Filament Bundle
Dendritic Shaft
Perikaryon
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Apical Dendrite
Postsynapse
Glutamatergic Synapse
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Adherens Junction
Bicellular Tight Junction
Lateral Plasma Membrane
Catenin Complex
Lamellipodium
Beta-catenin Destruction Complex
Ruffle Membrane
Perinuclear Region Of Cytoplasm
Wnt Signalosome
Molecular Function
G Protein-coupled Receptor Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Kinase Binding
Small GTPase Binding
Mu-type Opioid Receptor Binding
Fc-gamma Receptor I Complex Binding
Protein Homodimerization Activity
Ion Channel Binding
Cadherin Binding
SMAD Binding
Actin Filament Binding
GTPase Binding
Protein Binding
Beta-catenin Binding
Microtubule Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Gamma-catenin Binding
Cadherin Binding
Microtubule Plus-end Binding
Dynein Complex Binding
Biological Process
Angiogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Platelet Degranulation
Heart Morphogenesis
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Transcription By RNA Polymerase I
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Platelet Activation
Regulation Of Cell Migration
Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Filament Bundle Assembly
Cell Junction Assembly
Protein Localization To Cell Surface
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Import Into Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of DNA-binding Transcription Factor Activity
Wound Healing, Spreading Of Cells
Early Endosome To Late Endosome Transport
Establishment Of Protein Localization
Cell-cell Junction Organization
Positive Regulation Of Axon Regeneration
Synapse Organization
Protein Stabilization
Cytoplasmic Sequestering Of Protein
Defense Response To Virus
Actin Crosslink Formation
Cilium Assembly
Platelet Aggregation
Semaphorin-plexin Signaling Pathway
Protein Localization To Plasma Membrane
Tubulin Deacetylation
Mitotic Spindle Assembly
Establishment Of Sertoli Cell Barrier
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Potassium Ion Transmembrane Transport
Protein Localization To Bicellular Tight Junction
Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential
Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Integrin-mediated Signaling Pathway
Positive Regulation Of Neuron Migration
Mitotic Cytokinesis
Cell Fate Specification
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Microtubule Depolymerization
Cell Cycle Arrest
Mitotic Spindle Assembly Checkpoint
Cell Adhesion
Pattern Specification Process
Nervous System Development
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Positive Regulation Of Cell Death
Wnt Signaling Pathway
Cell Migration
Protein Deubiquitination
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Regulation Of Microtubule-based Process
Positive Regulation Of Apoptotic Process
Regulation Of Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Protein Localization To Centrosome
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Platelet degranulation
GP1b-IX-V activation signalling
Cell-extracellular matrix interactions
RHO GTPases activate PAKs
OAS antiviral response
Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Deactivation of the beta-catenin transactivating complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ovarian tumor domain proteases
Drugs
Artenimol
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
Periventricular nodular heterotopia (PVNH)
FG syndrome (FGS); Opitz-Kaveggia syndrome
Familial adenomatous polyposis
Esophageal cancer
Gastric cancer
Cancer of the anal canal
Gallbladder cancer
GWAS
Immature fraction of reticulocytes (
32888494
)
White blood cell count (
32888494
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Body mass index (
29273807
)
Colorectal cancer or advanced adenoma (
30510241
)
Heel bone mineral density (
30598549
)
Reaction time (
29844566
)
Total body bone mineral density (
29304378
)
Interacting Genes
98 interacting genes:
ADAMTSL4
APC
AR
ARHGAP24
ARRB1
ARRB2
ASB2
BRCA1
BRCA2
CALCR
CAMK2G
CASR
CAV1
CCNB1
CDC42
CEACAM1
CMIP
DCN
DDIT4L
DRD1
DRD2
DRD3
DUX4
ERBB3
F3
FABP1
FBLIM1
FILIP1
FLNB
FURIN
GP1BA
GRIK1
GRIK3
GRM4
GRM5
GRM7
GRM8
HHLA3
HNRNPD
HSPA6
HSPB7
ITGB1
ITGB3
ITGB5
ITGB6
ITGB7
KCNE4
KCNJ2
KLHL12
LGALS14
LMNA
MAP2K4
MAPK14
MCPH1
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
NLGN3
NPHP1
OPRM1
PAK1
PCBP2
PELO
PHOSPHO2
PLEKHF2
PRKCA
PSEN1
PSEN2
RAC1
RALA
REL
RFLNA
RHOA
SELE
SH2B3
SHBG
SIGLEC10
SIRPA
SMAD3
SMAD5
SPANXD
SRC
SUMO2
SVIL
SYNPO2
TCF4
TLR10
TNIP2
TP73
TRAF2
TRIM55
TRIO
TTN
USP19
VHL
YWHAG
138 interacting genes:
ACTN1
ADGRL1
AGFG1
AGR3
ANKRD17
ANP32B
ANXA7
AP2B1
ARHGEF4
ASAP2
AXIN1
AXIN2
BAAT
BUB1
BUB1B
C4A
CASC3
CCL5
CGNL1
COG4
COG5
CREBBP
CSNK1A1
CSNK1E
CTBP1
CTNNA1
CTNNB1
CTSV
CYP17A1
CYTH2
DIRAS3
DKK3
DLG3
DLGAP1
DST
EPAS1
ERBIN
EXPH5
FAM214A
FANCC
FBP1
FBXO30
FHOD1
FLNA
GIGYF2
GOLGA2
GSK3B
HGS
HNRNPM
HOXC6
HSPA5
HTRA2
IL24
ING5
IQGAP1
JUP
KIAA1328
KIF5B
KIFAP3
KRT13
KRT14
KRT15
KRT17
KRT19
KRT23
KRT5
LAMA3
LAMA4
MACF1
MAP2K1
MAPRE1
MAPRE2
MBD5
MCM3AP
MKRN1
MT-ND4
MUC1
MYH10
MYH11
MYO6
NANS
NAT2
NAV1
NAV2
NAV3
NCKAP5
NCKAP5L
NEB
NOSTRIN
NUP153
NUP214
NUP42
NUP54
NUP58
NUP98
PDLIM2
PNISR
POM121
POM121C
PPP1R13B
PPP2CA
PPP2R5A
PPP3R2
PRKACA
PSMD1
PTPN13
RANBP9
RASA1
RBM4B
RP1
RPS27
SCRIB
SEC31A
SETDB1
SIAH1
SMAD1
SMC3
SNRNP200
SPECC1L
SPTBN1
SPTBN2
ST14
SYNE1
TAF1
TFAP2A
TFF1
TGFB1
TMEFF1
TMOD1
TPR
TRIM21
TRIM25
TSTD2
TUBA4A
XPO1
YWHAQ
ZNF106
ZNF510
Entrez ID
2316
324
HPRD ID
02060
01439
Ensembl ID
ENSG00000196924
ENSG00000134982
Uniprot IDs
P21333
Q60FE5
Q6NXF2
P25054
Q4LE70
PDB IDs
2AAV
2BP3
2BRQ
2J3S
2JF1
2K3T
2K7P
2K7Q
2MTP
2W0P
2WFN
3CNK
3HOC
3HOP
3HOR
3ISW
3RGH
4M9P
4P3W
5XR1
6D8C
6EW1
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
4YJE
4YJL
4YK6
5B6G
5IZ6
5IZ8
5IZ9
5IZA
5Z8H
Enriched GO Terms of Interacting Partners
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