FLNA and CALCR

Data Source:
HPRD (in vivo, two hybrid)

		FLNA	CALCR
Description		filamin A	calcitonin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Z Disc Cortical Cytoskeleton Myb Complex Actin Filament Bundle Dendritic Shaft Perikaryon Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Apical Dendrite Postsynapse Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Axon Amylin Receptor Complex 1 Amylin Receptor Complex 2 Amylin Receptor Complex 3
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Protein Kinase C Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Kinase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Ion Channel Binding Cadherin Binding SMAD Binding Actin Filament Binding GTPase Binding	Amyloid-beta Binding Calcitonin Gene-related Peptide Receptor Activity Calcitonin Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Calcitonin Binding Amylin Receptor Activity
	Biological Process	Angiogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Platelet Degranulation Heart Morphogenesis Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Platelet Activation Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Early Endosome To Late Endosome Transport Establishment Of Protein Localization Cell-cell Junction Organization Positive Regulation Of Axon Regeneration Synapse Organization Protein Stabilization Cytoplasmic Sequestering Of Protein Defense Response To Virus Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of Cell Death Positive Regulation Of Peptidyl-serine Phosphorylation Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer Response To Glucocorticoid Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Amylin Receptor Signaling Pathway Response To Amyloid-beta Positive Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Artenimol	Salmon calcitonin Pramlintide
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia Periventricular nodular heterotopia (PVNH) FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Immature fraction of reticulocytes ( 32888494) White blood cell count ( 32888494)	Birth weight ( 23202124) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062 25760438 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Hip circumference ( 28552196 25673412) Lean body mass ( 28552196 28724990) Type 2 diabetes ( 32499647) Weight ( 28552196)
Interacting Genes		98 interacting genes: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DDIT4L DRD1 DRD2 DRD3 DUX4 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HHLA3 HNRNPD HSPA6 HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MYOT MYOZ1 NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PELO PHOSPHO2 PLEKHF2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RFLNA RHOA SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SPANXD SRC SUMO2 SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG	9 interacting genes: CALM1 FLNA GPRASP1 GPRASP2 MBL2 RAMP1 RAMP3 SQSTM1 THBS1
Entrez ID		2316	799
HPRD ID		02060	00239
Ensembl ID		ENSG00000196924	ENSG00000004948
Uniprot IDs		P21333 Q60FE5 Q6NXF2	A0A0C4DG16 P30988
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1	5II0 5UZ7 6NIY 6PFO 6PGQ
Enriched GO Terms of Interacting Partners?
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