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FLNA and RALA
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vitro, in vivo)
FLNA
RALA
Description
filamin A
RAS like proto-oncogene A
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleolus
Cytoplasm
Trans-Golgi Network
Cytosol
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Z Disc
Cortical Cytoskeleton
Myb Complex
Actin Filament Bundle
Dendritic Shaft
Perikaryon
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Apical Dendrite
Postsynapse
Glutamatergic Synapse
Plasma Membrane
Focal Adhesion
Cell Surface
Endocytic Vesicle
Cytoplasmic Vesicle Membrane
Cleavage Furrow
Extracellular Exosome
Flemming Body
Molecular Function
G Protein-coupled Receptor Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Kinase Binding
Small GTPase Binding
Mu-type Opioid Receptor Binding
Fc-gamma Receptor I Complex Binding
Protein Homodimerization Activity
Ion Channel Binding
Cadherin Binding
SMAD Binding
Actin Filament Binding
GTPase Binding
GTPase Activity
Protein Binding
GTP Binding
Myosin Binding
GDP Binding
Ubiquitin Protein Ligase Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
ATPase Binding
Biological Process
Angiogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Platelet Degranulation
Heart Morphogenesis
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Transcription By RNA Polymerase I
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Platelet Activation
Regulation Of Cell Migration
Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Filament Bundle Assembly
Cell Junction Assembly
Protein Localization To Cell Surface
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Import Into Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of DNA-binding Transcription Factor Activity
Wound Healing, Spreading Of Cells
Early Endosome To Late Endosome Transport
Establishment Of Protein Localization
Cell-cell Junction Organization
Positive Regulation Of Axon Regeneration
Synapse Organization
Protein Stabilization
Cytoplasmic Sequestering Of Protein
Defense Response To Virus
Actin Crosslink Formation
Cilium Assembly
Platelet Aggregation
Semaphorin-plexin Signaling Pathway
Protein Localization To Plasma Membrane
Tubulin Deacetylation
Mitotic Spindle Assembly
Establishment Of Sertoli Cell Barrier
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Potassium Ion Transmembrane Transport
Protein Localization To Bicellular Tight Junction
Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential
Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Integrin-mediated Signaling Pathway
Positive Regulation Of Neuron Migration
Neural Tube Closure
Exocytosis
Chemotaxis
Cell Cycle
Signal Transduction
Ras Protein Signal Transduction
Regulation Of Exocytosis
Actin Cytoskeleton Reorganization
Interleukin-12-mediated Signaling Pathway
Cell Division
Positive Regulation Of Filopodium Assembly
Membrane Raft Localization
Membrane Organization
Pathways
Platelet degranulation
GP1b-IX-V activation signalling
Cell-extracellular matrix interactions
RHO GTPases activate PAKs
OAS antiviral response
Translocation of SLC2A4 (GLUT4) to the plasma membrane
p38MAPK events
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Artenimol
Guanosine-5'-Diphosphate
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
Periventricular nodular heterotopia (PVNH)
FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS
Immature fraction of reticulocytes (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
98 interacting genes:
ADAMTSL4
APC
AR
ARHGAP24
ARRB1
ARRB2
ASB2
BRCA1
BRCA2
CALCR
CAMK2G
CASR
CAV1
CCNB1
CDC42
CEACAM1
CMIP
DCN
DDIT4L
DRD1
DRD2
DRD3
DUX4
ERBB3
F3
FABP1
FBLIM1
FILIP1
FLNB
FURIN
GP1BA
GRIK1
GRIK3
GRM4
GRM5
GRM7
GRM8
HHLA3
HNRNPD
HSPA6
HSPB7
ITGB1
ITGB3
ITGB5
ITGB6
ITGB7
KCNE4
KCNJ2
KLHL12
LGALS14
LMNA
MAP2K4
MAPK14
MCPH1
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
NLGN3
NPHP1
OPRM1
PAK1
PCBP2
PELO
PHOSPHO2
PLEKHF2
PRKCA
PSEN1
PSEN2
RAC1
RALA
REL
RFLNA
RHOA
SELE
SH2B3
SHBG
SIGLEC10
SIRPA
SMAD3
SMAD5
SPANXD
SRC
SUMO2
SVIL
SYNPO2
TCF4
TLR10
TNIP2
TP73
TRAF2
TRIM55
TRIO
TTN
USP19
VHL
YWHAG
30 interacting genes:
ARF1
CALM1
CNKSR2
CTCF
EXOC1
EXOC2
EXOC3
EXOC4
EXOC5
EXOC6B
EXOC7
EXOC8
FLNA
GLS2
HSPB1
LSM2
PIH1D2
PLCD1
PLD1
PPP2R1B
RAB34
RAB8B
RALBP1
RALGPS1
RASSF5
REPS1
RGL2
RGL4
SMAD4
YBX3
Entrez ID
2316
5898
HPRD ID
02060
01549
Ensembl ID
ENSG00000196924
ENSG00000006451
Uniprot IDs
P21333
Q60FE5
Q6NXF2
P11233
PDB IDs
2AAV
2BP3
2BRQ
2J3S
2JF1
2K3T
2K7P
2K7Q
2MTP
2W0P
2WFN
3CNK
3HOC
3HOP
3HOR
3ISW
3RGH
4M9P
4P3W
5XR1
6D8C
6EW1
1UAD
1ZC3
1ZC4
2A78
2A9K
2BOV
6P0I
6P0J
6P0K
6P0L
6P0M
6P0N
6P0O
Enriched GO Terms of Interacting Partners
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