Description |
presenilin 1 |
notch receptor 4 |
Image |
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No pdb structure |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
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- Advanced glycation end-product levels ( 26083729)
- Age-related macular degeneration ( 22694956)
- Aspartate aminotransferase levels ( 29403010)
- Asthma ( 21804548 31619474)
- Autism spectrum disorder or schizophrenia ( 28540026)
- Bipolar disorder ( 31043756)
- Blood protein levels ( 28240269)
- Blood protein levels in cardiovascular risk ( 28369058)
- Chronic hepatitis B infection ( 25802187)
- Circulating myeloperoxidase levels (serum) ( 23620142)
- Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947)
- Colorectal cancer ( 30529582)
- Crohn's disease ( 23266558)
- Epstein-Barr virus immune response (EBNA-1) ( 23326239)
- Food antigen IgG levels ( 24962563)
- Hematocrit ( 32888494)
- Hemoglobin ( 32888494)
- High light scatter reticulocyte count ( 32888494)
- HIV-1 control ( 20041166)
- Inflammatory bowel disease ( 28067908)
- Iron status biomarkers (iron levels) ( 28334935)
- Joint mobility (Beighton score) ( 27182965)
- Longevity ( 30294719)
- Lung cancer ( 28604730)
- Lung cancer in ever smokers ( 28604730)
- Lupus nephritis in systemic lupus erythematosus ( 24925725)
- Migraine ( 27322543)
- Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430)
- Obesity-related traits ( 23251661)
- Objective response to lithium treatment in bipolar disorder ( 26503763)
- Prostate cancer ( 23535732)
- Reticulocyte count ( 32888494)
- Reticulocyte fraction of red cells ( 27863252)
- Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848)
- Schizophrenia ( 19571808 30285260 23894747)
- Squamous cell lung carcinoma ( 28604730)
- Systemic lupus erythematosus ( 21408207)
- Systemic sclerosis ( 21779181)
- Takayasu arteritis ( 25604533)
- Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
- Ulcerative colitis ( 24837172 28067908)
- Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
- Waist-to-hip ratio adjusted for body mass index ( 28448500)
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Interacting Genes |
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
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13 interacting genes:
DLL4
EGFL7
ELOC
FBXW7
MAML1
MAML2
MAML3
PSEN1
PSEN2
RBPJ
SMAD2
SMAD3
SMAD4
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Entrez ID |
5663 |
4855 |
HPRD ID |
00087 |
01290 |
Ensembl ID |
ENSG00000080815
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ENSG00000204301
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Uniprot IDs |
A0A024R6A3
A0A0S2Z4D2
P49768
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A0A1U9X983
Q99466
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PDB IDs |
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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