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PSEN1 and CASP3
Data Source:
HPRD
(in vivo, in vitro)
PSEN1
CASP3
Description
presenilin 1
caspase 3
Image
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nucleus
Nuclear Outer Membrane
Nucleoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Synaptic Vesicle
Cell Surface
Membrane
Integral Component Of Membrane
Aggresome
Apical Plasma Membrane
Z Disc
Cell Junction
Growth Cone
Neuromuscular Junction
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Ciliary Rootlet
Azurophil Granule Membrane
Sarcolemma
Neuron Projection
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Gamma-secretase Complex
Integral Component Of Presynaptic Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Death-inducing Signaling Complex
Neuronal Cell Body
Membrane Raft
Molecular Function
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
PDZ Domain Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Cadherin Binding
ATPase Binding
Growth Factor Receptor Binding
Protease Binding
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Death Receptor Binding
Protein Binding
Peptidase Activity
Phospholipase A2 Activator Activity
Protein-containing Complex Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPKK Activity
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Hematopoietic Progenitor Cell Differentiation
Astrocyte Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
Neural Retina Development
Protein Glycosylation
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Mitochondrial Transport
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Notch Receptor Processing
Learning Or Memory
Memory
Post-embryonic Development
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Neuron Projection Development
Protein Transport
Choline Transport
Synaptic Vesicle Targeting
Protein Processing
Cerebellum Development
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Embryonic Limb Morphogenesis
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Phosphorylation
Positive Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Ephrin Receptor Signaling Pathway
Astrocyte Activation
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Synapse Organization
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Sequestering Of Calcium Ion
Neuron Apoptotic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Resting Membrane Potential
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Dendritic Spine Development
Calcium Ion Transmembrane Transport
Modulation Of Age-related Behavioral Decline
Cell-cell Adhesion
L-glutamate Import Across Plasma Membrane
Cellular Response To Amyloid-beta
Negative Regulation Of Core Promoter Binding
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Positive Regulation Of Amyloid Fibril Formation
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Luteolysis
Response To Hypoxia
B Cell Homeostasis
Apoptotic DNA Fragmentation
Proteolysis
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Axonal Fasciculation
Heart Development
Sensory Perception Of Sound
Learning Or Memory
Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Response To UV
Response To Glucose
Response To X-ray
Regulation Of Macroautophagy
Protein Processing
Cytokine-mediated Signaling Pathway
Hippocampus Development
Neuron Differentiation
Keratinocyte Differentiation
Erythrocyte Differentiation
Platelet Formation
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Glial Cell Apoptotic Process
Response To Tumor Necrosis Factor
Response To Nicotine
Hippo Signaling
Wound Healing
Response To Drug
Response To Hydrogen Peroxide
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Neuron Apoptotic Process
Cell Fate Commitment
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Activated T Cell Proliferation
Response To Antibiotic
Neurotrophin TRK Receptor Signaling Pathway
Striated Muscle Cell Differentiation
Response To Glucocorticoid
Neuron Apoptotic Process
Anterior Neural Tube Closure
Leukocyte Apoptotic Process
Cellular Response To Staurosporine
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Execution Phase Of Apoptosis
Positive Regulation Of Amyloid-beta Formation
Pathways
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Apoptosis induced DNA fragmentation
Degradation of the extracellular matrix
Signaling by Hippo
NADE modulates death signalling
Stimulation of the cell death response by PAK-2p34
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via Dependence Receptors in the absence of ligand
Other interleukin signaling
Drugs
Pamidronic acid
Acetylsalicylic acid
Minocycline
5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
Emricasan
Incadronic acid
2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
[N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Glycyrrhizic acid
Diseases
Acne inversa; Hidradenitis supprativa
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Alzheimer's disease (AD)
GWAS
Apolipoprotein B levels (
32203549
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Blood protein levels (
28240269
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Kawasaki disease (
33106546
)
Interacting Genes
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
157 interacting genes:
ACIN1
ADD1
AFP
AIFM1
AKAP8
AKT1
APAF1
APP
AR
ARHGDIA
ARHGDIB
ARNT
ATG4D
ATN1
BCAP31
BCAR1
BCL2
BECN1
BID
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BLM
BMX
BRCA1
CAD
CASP10
CASP2
CASP4
CASP6
CASP7
CASP8
CASP9
CAST
CDC27
CDC42
CDH1
CDK11B
CDKN1A
CFLAR
COPS6
CRYAB
CTNNB1
CTTN
DBNL
DCC
DCTN1
DEDD
DFFA
DSG3
EIF2AK2
EIF2S1
EIF3J
EIF4B
EIF4G2
FYN
GATA1
GLRX
GMNN
GOLGA3
GORASP1
GRIPAP1
GSN
GZMB
HCLS1
HIP1
HMGB1
HNRNPU
HSPD1
HSPE1
HTT
IL16
IL18
KCNIP3
KRT18
LMNB1
LYN
MAP4K1
MAPK8
MAPK8IP3
MAPK9
MAPT
MCL1
MDC1
MDM2
MDM4
MEF2A
MET
MLH1
MYL3
NDUFS1
NEDD4
NFE2L2
NMT2
PAK2
PARG
PARP1
PDE10A
PDE5A
PICALM
PIP5K1A
PKN1
PKN2
PLA2G4A
PLA2G4B
PPP3CA
PRKCQ
PRKCZ
PRKDC
PSEN1
PSEN2
PSIP1
PSME3
PTBP1
PTGES3
PTMA
PXN
RABEP1
RAC1
RAD51
RASA1
RB1
RFC1
RNF2
ROCK1
SARS2
SLK
SNRNP70
SOCS5
SOHLH1
SP1
SPTAN1
SREBF2
SRF
SRP72
STAT1
STK24
STK3
STK4
TFAP2A
TGM2
THAP11
TNFSF10
TOP1
TRAF1
TRAF3
UBE4B
USO1
VAV1
VIM
WEE1
XIAP
YWHAE
YWHAG
ZBTB16
Entrez ID
5663
836
HPRD ID
00087
02799
Ensembl ID
ENSG00000080815
ENSG00000164305
Uniprot IDs
A0A024R6A3
A0A0S2Z4D2
P49768
P42574
PDB IDs
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
1CP3
1GFW
1I3O
1NME
1NMQ
1NMS
1PAU
1QX3
1RE1
1RHJ
1RHK
1RHM
1RHQ
1RHR
1RHU
2C1E
2C2K
2C2M
2C2O
2CDR
2CJX
2CJY
2CNK
2CNL
2CNN
2CNO
2DKO
2H5I
2H5J
2H65
2J30
2J31
2J32
2J33
2XYG
2XYH
2XYP
2XZD
2XZT
2Y0B
3DEH
3DEI
3DEJ
3DEK
3EDQ
3GJQ
3GJR
3GJS
3GJT
3H0E
3ITN
3KJF
3PCX
3PD0
3PD1
4DCJ
4DCO
4DCP
4EHA
4EHD
4EHF
4EHH
4EHK
4EHL
4EHN
4JJE
4JQY
4JQZ
4JR0
4PRY
4PS0
4QTX
4QTY
4QU0
4QU5
4QU8
4QU9
4QUA
4QUB
4QUD
4QUE
4QUG
4QUH
4QUI
4QUJ
4QUL
5I9B
5I9T
5IAB
5IAE
5IAG
5IAJ
5IAK
5IAN
5IAR
5IAS
5IBC
5IBP
5IBR
5IC4
Enriched GO Terms of Interacting Partners
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