FLNA and ITGB6

Data Source:
BioGRID (two hybrid)

		FLNA	ITGB6
Description		filamin A	integrin subunit beta 6
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Z Disc Cortical Cytoskeleton Myb Complex Actin Filament Bundle Dendritic Shaft Perikaryon Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Apical Dendrite Postsynapse Glutamatergic Synapse	Nucleoplasm Centrosome Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Cell Junction Integrin Alphav-beta6 Complex Receptor Complex
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Protein Kinase C Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Kinase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Ion Channel Binding Cadherin Binding SMAD Binding Actin Filament Binding GTPase Binding	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Angiogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Platelet Degranulation Heart Morphogenesis Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Platelet Activation Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Early Endosome To Late Endosome Transport Establishment Of Protein Localization Cell-cell Junction Organization Positive Regulation Of Axon Regeneration Synapse Organization Protein Stabilization Cytoplasmic Sequestering Of Protein Defense Response To Virus Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration	Cell Morphogenesis Inflammatory Response Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Surfactant Homeostasis Skin Development Viral Entry Into Host Cell Lung Alveolus Development Phospholipid Homeostasis Hard Palate Development Bone Development SMAD Protein Signal Transduction Bronchiole Development Langerhans Cell Differentiation Enamel Mineralization Cellular Response To Ionizing Radiation Transforming Growth Factor Beta Production Regulation Of Transforming Growth Factor Beta Activation
Pathways		Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response	Elastic fibre formation Molecules associated with elastic fibres Integrin cell surface interactions ECM proteoglycans
Drugs		Artenimol
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia Periventricular nodular heterotopia (PVNH) FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Immature fraction of reticulocytes ( 32888494) White blood cell count ( 32888494)	Asthma (childhood onset) ( 31036433) Eosinophil counts ( 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) Idiopathic membranous nephropathy ( 21323541) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Tourette syndrome ( 30818990) Type 2 diabetes ( 20418489) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		98 interacting genes: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DDIT4L DRD1 DRD2 DRD3 DUX4 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HHLA3 HNRNPD HSPA6 HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MYOT MYOZ1 NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PELO PHOSPHO2 PLEKHF2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RFLNA RHOA SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SPANXD SRC SUMO2 SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG	8 interacting genes: FHL2 FLNA FLNB FN1 ITGAV MAPK1 TGFB1 VTN
Entrez ID		2316	3694
HPRD ID		02060	00947
Ensembl ID		ENSG00000196924	ENSG00000115221
Uniprot IDs		P21333 Q60FE5 Q6NXF2	A0A087WXP3 B4E2B8 E9PEE8 P18564
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1	1LH9 4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?