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PSEN1 and ACTN1
Data Source:
BioGRID
(two hybrid)
PSEN1
ACTN1
Description
presenilin 1
actinin alpha 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nucleus
Nuclear Outer Membrane
Nucleoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Synaptic Vesicle
Cell Surface
Membrane
Integral Component Of Membrane
Aggresome
Apical Plasma Membrane
Z Disc
Cell Junction
Growth Cone
Neuromuscular Junction
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Ciliary Rootlet
Azurophil Granule Membrane
Sarcolemma
Neuron Projection
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Gamma-secretase Complex
Integral Component Of Presynaptic Membrane
Stress Fiber
Ruffle
Extracellular Region
Extracellular Space
Cytoplasm
Cytosol
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Fascia Adherens
Focal Adhesion
Z Disc
Platelet Alpha Granule Lumen
Pseudopodium
Cell Projection
Extracellular Exosome
Glutamatergic Synapse
Molecular Function
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
PDZ Domain Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Cadherin Binding
ATPase Binding
Growth Factor Receptor Binding
Double-stranded RNA Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Vinculin Binding
Nuclear Receptor Coactivator Activity
Protein Homodimerization Activity
Ion Channel Binding
Actin Filament Binding
Structural Constituent Of Postsynapse
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPKK Activity
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Hematopoietic Progenitor Cell Differentiation
Astrocyte Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
Neural Retina Development
Protein Glycosylation
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Mitochondrial Transport
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Notch Receptor Processing
Learning Or Memory
Memory
Post-embryonic Development
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Neuron Projection Development
Protein Transport
Choline Transport
Synaptic Vesicle Targeting
Protein Processing
Cerebellum Development
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Embryonic Limb Morphogenesis
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Phosphorylation
Positive Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Positive Regulation Of MAP Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Ephrin Receptor Signaling Pathway
Astrocyte Activation
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Synapse Organization
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Sequestering Of Calcium Ion
Neuron Apoptotic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Resting Membrane Potential
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Dendritic Spine Development
Calcium Ion Transmembrane Transport
Modulation Of Age-related Behavioral Decline
Cell-cell Adhesion
L-glutamate Import Across Plasma Membrane
Cellular Response To Amyloid-beta
Negative Regulation Of Core Promoter Binding
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Positive Regulation Of Amyloid Fibril Formation
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Platelet Degranulation
Actin Filament Organization
Platelet Activation
Platelet Formation
Platelet Morphogenesis
Regulation Of Apoptotic Process
Positive Regulation Of Transcription, DNA-templated
Focal Adhesion Assembly
Actin Filament Bundle Assembly
Negative Regulation Of Cellular Component Movement
Actin Filament Network Formation
Platelet Aggregation
Postsynapse Organization
Pathways
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Platelet degranulation
Syndecan interactions
Nephrin family interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Human calcitonin
Copper
Diseases
Acne inversa; Hidradenitis supprativa
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Alzheimer's disease (AD)
GWAS
Apolipoprotein B levels (
32203549
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Asthma (
31959851
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Feeling fed-up (
29500382
)
Feeling hurt (
29500382
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
)
High light scatter reticulocyte count (
32888494
)
Lack of perseverance (
30718321
)
Mean platelet volume (
32888494
27863252
)
Medication use (drugs used in diabetes) (
31015401
)
Mosquito bite size (
28199695
)
Neurociticism (
29500382
)
Periodontitis (Mean PAL) (
24024966
)
Platelet count (
26805783
29403010
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Prostate cancer (
23535732
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Smoking behavior (
19247474
)
Urinary albumin excretion (
30220432
)
Interacting Genes
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
90 interacting genes:
ACTN2
ACTN3
ADORA2A
APC
APPBP2
ATXN2
ATXN7
C14orf119
CACNA1A
CAMK2A
CBY2
CDK5
CDK5R1
CDK5R2
CLIC5
COIL
COL17A1
CSRP1
CSRP3
CTNNA1
DDIAS
DYNLT1
EIF2S1
EPM2AIP1
ERBIN
FBP1
FXN
GADD45G
GFI1B
GIPC1
GIT2
GRIA4
GRIN2A
GRM5
GTF2H1
HSPB1
ICAM5
ITGB1
KAT2B
KCTD6
KPNA2
LINC01554
LNX1
LPP
MAGEA11
MAP2
MAP3K1
MED14
MICALL2
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
MYOZ2
MYOZ3
NEBL
NKAPD1
NR1H3
NUMBL
OAS1
PALLD
PDHX
PDLIM1
PDLIM5
PIAS4
PKD1
PKN1
PLD2
PSEN1
PSMA1
PTK2
PTPN1
PTPN6
PYGB
RAVER1
RPS27
SIRPA
SLC2A4
SORBS2
SRC
SSX2IP
SYNPO2L
TES
TTN
TXN
USP2
VCL
XRCC4
ZYX
Entrez ID
5663
87
HPRD ID
00087
00020
Ensembl ID
ENSG00000080815
ENSG00000072110
Uniprot IDs
A0A024R6A3
A0A0S2Z4D2
P49768
A0A024R694
P12814
PDB IDs
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
2EYI
2EYN
2N8Y
2N8Z
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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