FLNA and MYOZ1

Data Source:
BioGRID (two hybrid)

		FLNA	MYOZ1
Description		filamin A	myozenin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Z Disc Cortical Cytoskeleton Myb Complex Actin Filament Bundle Dendritic Shaft Perikaryon Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Apical Dendrite Postsynapse Glutamatergic Synapse	Nucleus Actin Cytoskeleton Z Disc Pseudopodium
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Protein Kinase C Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Kinase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Ion Channel Binding Cadherin Binding SMAD Binding Actin Filament Binding GTPase Binding	Actin Binding Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Telethonin Binding FATZ Binding
	Biological Process	Angiogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Platelet Degranulation Heart Morphogenesis Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Platelet Activation Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Early Endosome To Late Endosome Transport Establishment Of Protein Localization Cell-cell Junction Organization Positive Regulation Of Axon Regeneration Synapse Organization Protein Stabilization Cytoplasmic Sequestering Of Protein Defense Response To Virus Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Myofibril Assembly Negative Regulation Of Phosphoprotein Phosphatase Activity Wound Healing Negative Regulation Of Skeletal Muscle Tissue Regeneration Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response
Drugs		Artenimol
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia Periventricular nodular heterotopia (PVNH) FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Immature fraction of reticulocytes ( 32888494) White blood cell count ( 32888494)	Atrial fibrillation ( 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		98 interacting genes: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DDIT4L DRD1 DRD2 DRD3 DUX4 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HHLA3 HNRNPD HSPA6 HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MYOT MYOZ1 NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PELO PHOSPHO2 PLEKHF2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RFLNA RHOA SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SPANXD SRC SUMO2 SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG	40 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 AKAP8L APP BAG4 BRCA1 CEACAM6 CEP76 CRX EIF3F EXOSC8 FLNA FLNC GOLGA6A GRB2 KRT34 KRT36 KRTAP12-2 LDB3 LHX4 LZTS2 MAGEA11 PFDN5 PLEKHG4 PNKP PNMA1 PRKAA2 TCAP TRAF1 TRIM23 TRIM55 TRIM63 USHBP1 VAC14 VBP1 WASHC3 WWOX YPEL3
Entrez ID		2316	58529
HPRD ID		02060	05725
Ensembl ID		ENSG00000196924	ENSG00000177791
Uniprot IDs		P21333 Q60FE5 Q6NXF2	Q9NP98
PDB IDs		2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1
Enriched GO Terms of Interacting Partners?
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